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• W2079702987 abstract "In transthyretin (TTR)-related amyloidosis, wild-type TTR (WT-TTR), as well as mutated TTRs play important roles in the pathogenesis of senile systemic amyloidosis and familial amyloidotic polyneuropathy. However, WT-TTR usually forms stable tetramers at physiological pH, and the mechanism of such fibril formation under physiological conditions remains to be elucidated. In this study, we demonstrated WT-TTR amyloid fibril formation at physiological pH with ultrasonication. Cross-linked SDS-PAGE and circular dichroism revealed that ultrasonication induced both tetrameric TTR dissociation and monomeric TTR denaturation. These results indicate that extremely low pH is not an essential condition for TTR amyloid fibril formation if TTR is degenerated in such conditions. In addition, this method allows analysis of accelerator factors or inhibitory agents in TTR amyloid fibril formation at neutral pH." @default.
• W2079702987 created "2016-06-24" @default.
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• W2079702987 date "2008-01-01" @default.
• W2079702987 modified "2023-09-26" @default.
• W2079702987 title "Transthyretin forms amyloid fibrils at physiological pH with ultrasonication" @default.
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• W2079702987 doi "https://doi.org/10.1080/13506120802524684" @default.
• W2079702987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19065294" @default.
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