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• W2080450059 abstract "<h2>Abstract</h2><h3>Background and aims</h3> Patients with chronic renal failure, especially those treated with haemodialysis, have an increased risk of developing atherosclerotic vascular disease probably as a result of enhanced oxidative stress. The human cell membrane possesses electron transfer systems which protect against extracellular pro-oxidant challenge. We evaluated (1) the erythrocyte velocity of ferricyanide reduction (RBC vfcy) in 25 uraemic patients (aged 25–71 years; 14 males), (2) the changes induced by a single haemodialysis session and (3) biomarkers of oxidative stress. <h3>Methods and results</h3> Before and after a mid-week dialysis session, we measured RBC vfcy, erythrocyte glutathione (RBC GSH), plasma and red cell membrane malondialdehyde (P and RBC MDA), plasma sulphydryl groups (P SH), plasma vitamin C levels and haemolysis percentage. Pre-dialysis RBC GSH (0.68±0.13 vs 0.80±0.13mg/mL, <i>p</i><0.01), P SH (266±74 vs 406±78μmol/L, <i>p</i><0.01) and plasma vitamin C (7.0±5.1 vs 21.5±8.5mg/L, <i>p</i><0.001) were lower than in 25 age-sex-matched healthy controls; P MDA (1.57±0.52 vs 0.54±0.29nmol/mL, <i>p</i><0.001), RBC MDA (0.42±0.13 vs 0.34±0.16nmol/mL, <i>p</i><0.05) and haemolysis (1.2±0.3 vs 0.7±0.3%, <i>p</i><0.001) were increased. Baseline RBC vfcy did not differ from normals (13.1±5.2 vs 12.9±3.2mmol/mL/h). Following dialysis, RBC vfcy (to 8.9±4.5mmol/mL/h, <i>p</i><0.001) decreased, as well as P MDA, RBC MDA and plasma vitamin C (to 2.5±1.4mg/L, <i>p</i><0.001), whereas P SH groups increased (to 413±99μmol/L, <i>p</i><0.001); haemolysis percentage remained high. RBC vfcy values were correlated to RBC GSH and vitamin C levels. <h3>Conclusions</h3> Uraemic patients showed signs of oxidative stress. Pre-dialysis RBC vfcy is maintained in the normal range on account of a reduced intracellular content of GSH and in spite of low plasma ascorbate. A single haemodialysis treatment reduced biomarkers of protein and lipid oxidation but markedly impaired transmembrane electron transfer, which could be explained by acute depletion of electron donors." @default.
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• W2080450059 date "2007-05-01" @default.
• W2080450059 modified "2023-09-26" @default.
• W2080450059 title "Erythrocyte transmembrane electron transfer in haemodialysis patients" @default.
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• W2080450059 doi "https://doi.org/10.1016/j.numecd.2005.11.011" @default.
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