FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080562857> ?p ?o ?g. }

• W2080562857 abstract "The association of mutation of the transforming growth factor beta (TGFbeta) type II receptor (RII) with microsatellite instability revealed a significant molecular mechanism of tumorigenesis and tumor progression in gastrointestinal carcinomas with DNA replication error. However, mutation of RII is rare in other types of carcinomas with microsatellite instability including endometrial adenocarcinoma suggesting that TGFbeta receptor signaling may be necessary for tumor progression. To test this hypothesis, we abrogated TGFbeta signaling with ectopic expression of a dominant-negative RII (DNRII) in human endometrial carcinoma HEC-1-A cells with microsatellite instability. Our study showed that over-expression of DNRII blocked the TGFbeta signaling, inhibited anchorage-dependent and -independent growth, and stimulated apoptosis in vitro. Interestingly, the expression of DNRII expression showed little effect on tumor growth of subcutaneously inoculated cells in vivo. On the other hand, the DNRII cells showed more epithelial features whereas the control cells showed more mesenchymal features suggesting a reversal of autocrine TGFbeta-induced epithelial-mesenchymal transition (EMT). Consistent with these findings, DNRII cells were much less migratory and invasive in vitro and metastatic in vivo than the control cells. Therefore, an intact TGFbeta signaling pathway appears necessary for the metastatic phenotypes of this carcinoma model." @default.
• W2080562857 created "2016-06-24" @default.
• W2080562857 creator A5009639926 @default.
• W2080562857 creator A5025589606 @default.
• W2080562857 creator A5027911001 @default.
• W2080562857 creator A5030611879 @default.
• W2080562857 date "2009-04-01" @default.
• W2080562857 modified "2023-09-25" @default.
• W2080562857 title "TGFβ signaling supports survival and metastasis of endometrial cancer cells" @default.
• W2080562857 cites W1513040830 @default.
• W2080562857 cites W1524314479 @default.
• W2080562857 cites W1529983307 @default.
• W2080562857 cites W1930083400 @default.
• W2080562857 cites W1976738458 @default.
• W2080562857 cites W1978177900 @default.
• W2080562857 cites W1980716385 @default.
• W2080562857 cites W1983628734 @default.
• W2080562857 cites W1987190996 @default.
• W2080562857 cites W1993312145 @default.
• W2080562857 cites W1998254907 @default.
• W2080562857 cites W1999332302 @default.
• W2080562857 cites W1999614450 @default.
• W2080562857 cites W2008259012 @default.
• W2080562857 cites W2009408163 @default.
• W2080562857 cites W2009629707 @default.
• W2080562857 cites W2009927859 @default.
• W2080562857 cites W2017201371 @default.
• W2080562857 cites W2022896763 @default.
• W2080562857 cites W2025083720 @default.
• W2080562857 cites W2035653659 @default.
• W2080562857 cites W2037038224 @default.
• W2080562857 cites W2049861779 @default.
• W2080562857 cites W2058297837 @default.
• W2080562857 cites W2063973314 @default.
• W2080562857 cites W2076583198 @default.
• W2080562857 cites W2077367461 @default.
• W2080562857 cites W2083713591 @default.
• W2080562857 cites W2089693511 @default.
• W2080562857 cites W2092513068 @default.
• W2080562857 cites W2094732490 @default.
• W2080562857 cites W2096662041 @default.
• W2080562857 cites W2097829282 @default.
• W2080562857 cites W2099580743 @default.
• W2080562857 cites W2105396692 @default.
• W2080562857 cites W2111991357 @default.
• W2080562857 cites W2112194601 @default.
• W2080562857 cites W2113989947 @default.
• W2080562857 cites W2117930450 @default.
• W2080562857 cites W2137393673 @default.
• W2080562857 cites W2146119340 @default.
• W2080562857 cites W2147865927 @default.
• W2080562857 cites W2150091603 @default.
• W2080562857 cites W2154657445 @default.
• W2080562857 cites W2165214867 @default.
• W2080562857 cites W2165711945 @default.
• W2080562857 cites W2168026694 @default.
• W2080562857 cites W2475426564 @default.
• W2080562857 cites W2148729333 @default.
• W2080562857 doi "https://doi.org/10.2147/cmar.s4545" @default.
• W2080562857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2901109" @default.
• W2080562857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20622970" @default.
• W2080562857 hasPublicationYear "2009" @default.
• W2080562857 type Work @default.
• W2080562857 sameAs 2080562857 @default.
• W2080562857 citedByCount "16" @default.
• W2080562857 countsByYear W20805628572012 @default.
• W2080562857 countsByYear W20805628572015 @default.
• W2080562857 countsByYear W20805628572016 @default.
• W2080562857 countsByYear W20805628572017 @default.
• W2080562857 countsByYear W20805628572018 @default.
• W2080562857 countsByYear W20805628572019 @default.
• W2080562857 countsByYear W20805628572021 @default.
• W2080562857 crossrefType "journal-article" @default.
• W2080562857 hasAuthorship W2080562857A5009639926 @default.
• W2080562857 hasAuthorship W2080562857A5025589606 @default.
• W2080562857 hasAuthorship W2080562857A5027911001 @default.
• W2080562857 hasAuthorship W2080562857A5030611879 @default.
• W2080562857 hasBestOaLocation W20805628571 @default.
• W2080562857 hasConcept C104317684 @default.
• W2080562857 hasConcept C118131993 @default.
• W2080562857 hasConcept C121608353 @default.
• W2080562857 hasConcept C128240485 @default.
• W2080562857 hasConcept C170493617 @default.
• W2080562857 hasConcept C180754005 @default.
• W2080562857 hasConcept C2778229498 @default.
• W2080562857 hasConcept C2779013556 @default.
• W2080562857 hasConcept C2779256057 @default.
• W2080562857 hasConcept C2779767149 @default.
• W2080562857 hasConcept C502942594 @default.
• W2080562857 hasConcept C54355233 @default.
• W2080562857 hasConcept C555283112 @default.
• W2080562857 hasConcept C61320498 @default.
• W2080562857 hasConcept C62478195 @default.
• W2080562857 hasConcept C76419328 @default.
• W2080562857 hasConcept C7876069 @default.
• W2080562857 hasConcept C81885089 @default.
• W2080562857 hasConcept C86803240 @default.
• W2080562857 hasConcept C95444343 @default.
• W2080562857 hasConcept C97037327 @default.
• W2080562857 hasConceptScore W2080562857C104317684 @default.

• next