FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081103615> ?p ?o ?g. }

• W2081103615 endingPage "5163" @default.
• W2081103615 startingPage "5159" @default.
• W2081103615 abstract "Srp1p, the protein encoded by SRP1 of Saccharomyces cerevisiae, is a nuclear-pore-associated protein. Its Xenopus homolog, importin, was recently shown to be an essential component required for nuclear localization signal (NLS)-dependent binding of karyophilic proteins to the nuclear envelope [Gorlich, D., Prehn, S., Laskey, R. A. & Hartman, E. (1994) Cell 79, 767-778]. We have discovered a protein kinase whose activity is stimulated by Srp1p (Srp1p fused to glutathione S-transferase and expressed in Escherichia coli) and is detected by phosphorylation of Srp1p and of a 36-kDa protein, a component of the protein kinase complex. The enzyme, called Srp1p kinase, is a protein-serine kinase and was found in extracts in two related complexes of approximately 180 kDa and 220 kDa. The second complex, when purified, contained four protein components including the 36-kDa protein. We observed that, upon purification of the kinase, phosphorylation of Srp1p became very weak, while activation of phosphorylation of the 36-kDa protein by Srp1p remained unaltered. Significantly, NLS peptides and the nuclear proteins we have tested greatly stimulated phosphorylation of Srp1p, suggesting that Srp1p, complexed with karyophilic proteins carrying an NLS, is the in vivo substrate of this protein kinase." @default.
• W2081103615 created "2016-06-24" @default.
• W2081103615 creator A5044811616 @default.
• W2081103615 creator A5060667235 @default.
• W2081103615 creator A5061561245 @default.
• W2081103615 creator A5072834548 @default.
• W2081103615 date "1995-05-23" @default.
• W2081103615 modified "2023-09-26" @default.
• W2081103615 title "Isolation of a yeast protein kinase that is activated by the protein encoded by SRP1 (Srp1p) and phosphorylates Srp1p complexed with nuclear localization signal peptides." @default.
• W2081103615 cites W1563799601 @default.
• W2081103615 cites W1687563194 @default.
• W2081103615 cites W1902070349 @default.
• W2081103615 cites W1923414648 @default.
• W2081103615 cites W1939013880 @default.
• W2081103615 cites W1972696767 @default.
• W2081103615 cites W1984956543 @default.
• W2081103615 cites W2011147958 @default.
• W2081103615 cites W2029306713 @default.
• W2081103615 cites W2048755377 @default.
• W2081103615 cites W2054370975 @default.
• W2081103615 cites W2057493866 @default.
• W2081103615 cites W2059591425 @default.
• W2081103615 cites W2071957053 @default.
• W2081103615 cites W2080894230 @default.
• W2081103615 cites W2087302056 @default.
• W2081103615 cites W2093835976 @default.
• W2081103615 cites W2120226363 @default.
• W2081103615 cites W2125778361 @default.
• W2081103615 cites W2147488894 @default.
• W2081103615 cites W2165562991 @default.
• W2081103615 cites W255772229 @default.
• W2081103615 doi "https://doi.org/10.1073/pnas.92.11.5159" @default.
• W2081103615 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/41868" @default.
• W2081103615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7761467" @default.
• W2081103615 hasPublicationYear "1995" @default.
• W2081103615 type Work @default.
• W2081103615 sameAs 2081103615 @default.
• W2081103615 citedByCount "23" @default.
• W2081103615 countsByYear W20811036152018 @default.
• W2081103615 countsByYear W20811036152019 @default.
• W2081103615 crossrefType "journal-article" @default.
• W2081103615 hasAuthorship W2081103615A5044811616 @default.
• W2081103615 hasAuthorship W2081103615A5060667235 @default.
• W2081103615 hasAuthorship W2081103615A5061561245 @default.
• W2081103615 hasAuthorship W2081103615A5072834548 @default.
• W2081103615 hasBestOaLocation W20811036151 @default.
• W2081103615 hasConcept C104317684 @default.
• W2081103615 hasConcept C11960822 @default.
• W2081103615 hasConcept C153911025 @default.
• W2081103615 hasConcept C159479382 @default.
• W2081103615 hasConcept C171896709 @default.
• W2081103615 hasConcept C175738201 @default.
• W2081103615 hasConcept C184235292 @default.
• W2081103615 hasConcept C29512474 @default.
• W2081103615 hasConcept C49805395 @default.
• W2081103615 hasConcept C55493867 @default.
• W2081103615 hasConcept C82495950 @default.
• W2081103615 hasConcept C86339819 @default.
• W2081103615 hasConcept C86803240 @default.
• W2081103615 hasConcept C87325107 @default.
• W2081103615 hasConcept C90934575 @default.
• W2081103615 hasConcept C97029542 @default.
• W2081103615 hasConcept C99405784 @default.
• W2081103615 hasConceptScore W2081103615C104317684 @default.
• W2081103615 hasConceptScore W2081103615C11960822 @default.
• W2081103615 hasConceptScore W2081103615C153911025 @default.
• W2081103615 hasConceptScore W2081103615C159479382 @default.
• W2081103615 hasConceptScore W2081103615C171896709 @default.
• W2081103615 hasConceptScore W2081103615C175738201 @default.
• W2081103615 hasConceptScore W2081103615C184235292 @default.
• W2081103615 hasConceptScore W2081103615C29512474 @default.
• W2081103615 hasConceptScore W2081103615C49805395 @default.
• W2081103615 hasConceptScore W2081103615C55493867 @default.
• W2081103615 hasConceptScore W2081103615C82495950 @default.
• W2081103615 hasConceptScore W2081103615C86339819 @default.
• W2081103615 hasConceptScore W2081103615C86803240 @default.
• W2081103615 hasConceptScore W2081103615C87325107 @default.
• W2081103615 hasConceptScore W2081103615C90934575 @default.
• W2081103615 hasConceptScore W2081103615C97029542 @default.
• W2081103615 hasConceptScore W2081103615C99405784 @default.
• W2081103615 hasIssue "11" @default.
• W2081103615 hasLocation W20811036151 @default.
• W2081103615 hasLocation W20811036152 @default.
• W2081103615 hasLocation W20811036153 @default.
• W2081103615 hasLocation W20811036154 @default.
• W2081103615 hasOpenAccess W2081103615 @default.
• W2081103615 hasPrimaryLocation W20811036151 @default.
• W2081103615 hasRelatedWork W1967071341 @default.
• W2081103615 hasRelatedWork W1992848268 @default.
• W2081103615 hasRelatedWork W1994635740 @default.
• W2081103615 hasRelatedWork W2050961751 @default.
• W2081103615 hasRelatedWork W2061404590 @default.
• W2081103615 hasRelatedWork W2078744339 @default.
• W2081103615 hasRelatedWork W2081103615 @default.
• W2081103615 hasRelatedWork W2088360874 @default.
• W2081103615 hasRelatedWork W2119630325 @default.
• W2081103615 hasRelatedWork W2416604852 @default.
• W2081103615 hasVolume "92" @default.

• next