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- W2083377464 abstract "Aim: The aim of this study was to measure GABAA benzodiazepine receptor (GBzR) sensitivity in alcohol-dependent patients and compare with matched non-dependent drinkers. Methods: Nine abstinent alcohol-dependent male patients, age matched with nine male non-dependent social drinkers, received an intravenous infusion of midazolam. Objective (saccadic eye movement slowing) and subjective (visual analogue scales) measurements were recorded at 15-min intervals for 2 h. Results: There were no differences in objective or subjective measures. Conclusions: Our hypothesis that patients with alcohol dependence would have less slowing of their eye movements in response to this challenge, reflecting reduced GBzR sensitivity, was not confirmed. The reasons for this could mean that GBzR function returns to normal with abstinence, or that this paradigm is unable to measure the subtle subtype-specific changes in GBzR sensitivity that occur following dependent alcohol use." @default.
- W2083377464 created "2016-06-24" @default.
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- W2083377464 date "2008-01-01" @default.
- W2083377464 modified "2023-10-16" @default.
- W2083377464 title "Assessment of GABAABenzodiazepine Receptor (GBzR) Sensitivity in Patients with Alcohol Dependence" @default.
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- W2083377464 doi "https://doi.org/10.1093/alcalc/agn056" @default.
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