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• W2085149748 abstract "Stochastic or Asymmetric Fate Determination? During an adaptive immune response, B lymphocytes rapidly divide and differentiate into effector cell populations, including antibody-secreting plasmablasts and memory B cells. Many also change the class of antibody they secrete, through a process called isotype switching. During this process, some cells die. Whether cells acquire these different fates in a stochastic or programmed manner, however, is unclear. Duffy et al. (p. 338 , published online 5 January) used single-cell tracking to determine the times to division, differentiation into a plasmablast, isotype switching, and death of stimulated B lymphocytes. Statistical analysis and mathematical modeling revealed that these cell-fate decisions appear to be the result of random clocks: Which clock went off first (division, differentiation, or death), determined the fate of the cell. Barnett et al. (p. 342 , published online 15 December) sought to determine whether asymmetrical cell division, which is thought to contribute to effector cell-fate decisions in T cells, may be at work in B lymphocytes. Indeed, factors important for the initiation and maintenance of germinal center B lymphocyte identity, along with an ancestral polarity protein, were asymmetrically distributed and maintained their asymmetry during cell division." @default.
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• W2085149748 date "2012-01-20" @default.
• W2085149748 modified "2023-09-25" @default.
• W2085149748 title "Activation-Induced B Cell Fates Are Selected by Intracellular Stochastic Competition" @default.
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• W2085149748 doi "https://doi.org/10.1126/science.1213230" @default.
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