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- W2086014798 abstract "We utilized the Cre-LoxP system to establish erbB2 conditional mutant mice in order to investigate the role of erbB2 in postnatal development of the enteric nervous system. The erbB2/nestin-Cre conditional mutants exhibit retarded growth, distended colons, and premature death, resembling human Hirschsprung's disease. Enteric neurons and glia are present at birth in the colon of erbB2/nestin-Cre mutants; however, a marked loss of multiple classes of enteric neurons and glia occurs by 3 weeks of age. Furthermore, we demonstrate that the requirement for erbB2 in maintaining the enteric nervous system is not cell autonomous, but rather erbB2 signaling in the colonic epithelia is required for the postnatal survival of enteric neurons and glia." @default.
- W2086014798 created "2016-06-24" @default.
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- W2086014798 date "2003-01-01" @default.
- W2086014798 modified "2023-10-01" @default.
- W2086014798 title "Colonic Epithelial Expression of ErbB2 Is Required for Postnatal Maintenance of the Enteric Nervous System" @default.
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- W2086014798 doi "https://doi.org/10.1016/s0896-6273(02)01128-5" @default.
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