Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086702905> ?p ?o ?g. }
- W2086702905 abstract "Replication helps ensure that a genotype-phenotype association observed in a genome-wide association (GWA) study represents a credible association and is not a chance finding or an artifact due to uncontrolled biases. We discuss prerequisites for exact replication, issues of heterogeneity, advantages and disadvantages of different methods of data synthesis across multiple studies, frequentist vs. Bayesian inferences for replication, and challenges that arise from multi-team collaborations. While consistent replication can greatly improve the credibility of a genotype-phenotype association, it may not eliminate spurious associations due to biases shared by many studies. Conversely, lack of replication in well-powered follow-up studies usually invalidates the initially proposed association, although occasionally it may point to differences in linkage disequilibrium or effect modifiers across studies." @default.
- W2086702905 created "2016-06-24" @default.
- W2086702905 creator A5044451947 @default.
- W2086702905 creator A5056487867 @default.
- W2086702905 creator A5070446713 @default.
- W2086702905 date "2009-11-01" @default.
- W2086702905 modified "2023-10-14" @default.
- W2086702905 title "Replication in Genome-Wide Association Studies" @default.
- W2086702905 cites W1509374256 @default.
- W2086702905 cites W1556717463 @default.
- W2086702905 cites W1944558458 @default.
- W2086702905 cites W1978097115 @default.
- W2086702905 cites W1979791496 @default.
- W2086702905 cites W1983728797 @default.
- W2086702905 cites W1984056503 @default.
- W2086702905 cites W1992882281 @default.
- W2086702905 cites W1996819439 @default.
- W2086702905 cites W1998641738 @default.
- W2086702905 cites W1998957301 @default.
- W2086702905 cites W2006624426 @default.
- W2086702905 cites W2013524758 @default.
- W2086702905 cites W2017079501 @default.
- W2086702905 cites W2017136882 @default.
- W2086702905 cites W2018986622 @default.
- W2086702905 cites W2024670158 @default.
- W2086702905 cites W2040228409 @default.
- W2086702905 cites W2043463953 @default.
- W2086702905 cites W2046387635 @default.
- W2086702905 cites W2048011602 @default.
- W2086702905 cites W2048258507 @default.
- W2086702905 cites W2048755332 @default.
- W2086702905 cites W2055433848 @default.
- W2086702905 cites W2057933447 @default.
- W2086702905 cites W2063097062 @default.
- W2086702905 cites W2063119504 @default.
- W2086702905 cites W2067964903 @default.
- W2086702905 cites W2071348149 @default.
- W2086702905 cites W2082122713 @default.
- W2086702905 cites W2091806847 @default.
- W2086702905 cites W2097660065 @default.
- W2086702905 cites W2097902492 @default.
- W2086702905 cites W2098161436 @default.
- W2086702905 cites W2101983393 @default.
- W2086702905 cites W2102945991 @default.
- W2086702905 cites W2108116635 @default.
- W2086702905 cites W2114005874 @default.
- W2086702905 cites W2114688149 @default.
- W2086702905 cites W2117200377 @default.
- W2086702905 cites W2119067354 @default.
- W2086702905 cites W2124163128 @default.
- W2086702905 cites W2126930838 @default.
- W2086702905 cites W2127190573 @default.
- W2086702905 cites W2128201302 @default.
- W2086702905 cites W2129150286 @default.
- W2086702905 cites W2130259798 @default.
- W2086702905 cites W2130947914 @default.
- W2086702905 cites W2131935357 @default.
- W2086702905 cites W2132981035 @default.
- W2086702905 cites W2134783591 @default.
- W2086702905 cites W2140040043 @default.
- W2086702905 cites W2140126911 @default.
- W2086702905 cites W2140908395 @default.
- W2086702905 cites W2144856997 @default.
- W2086702905 cites W2144981148 @default.
- W2086702905 cites W2147669721 @default.
- W2086702905 cites W2149182120 @default.
- W2086702905 cites W2149791927 @default.
- W2086702905 cites W2150215887 @default.
- W2086702905 cites W2151773390 @default.
- W2086702905 cites W2151789140 @default.
- W2086702905 cites W2155449815 @default.
- W2086702905 cites W2157752701 @default.
- W2086702905 cites W2163184920 @default.
- W2086702905 cites W2165872127 @default.
- W2086702905 cites W2166462835 @default.
- W2086702905 cites W2314620760 @default.
- W2086702905 cites W2330813625 @default.
- W2086702905 cites W4230810535 @default.
- W2086702905 cites W4247938048 @default.
- W2086702905 doi "https://doi.org/10.1214/09-sts290" @default.
- W2086702905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2865141" @default.
- W2086702905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20454541" @default.
- W2086702905 hasPublicationYear "2009" @default.
- W2086702905 type Work @default.
- W2086702905 sameAs 2086702905 @default.
- W2086702905 citedByCount "226" @default.
- W2086702905 countsByYear W20867029052012 @default.
- W2086702905 countsByYear W20867029052013 @default.
- W2086702905 countsByYear W20867029052014 @default.
- W2086702905 countsByYear W20867029052015 @default.
- W2086702905 countsByYear W20867029052016 @default.
- W2086702905 countsByYear W20867029052017 @default.
- W2086702905 countsByYear W20867029052018 @default.
- W2086702905 countsByYear W20867029052019 @default.
- W2086702905 countsByYear W20867029052020 @default.
- W2086702905 countsByYear W20867029052021 @default.
- W2086702905 countsByYear W20867029052022 @default.
- W2086702905 countsByYear W20867029052023 @default.
- W2086702905 crossrefType "journal-article" @default.
- W2086702905 hasAuthorship W2086702905A5044451947 @default.