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• W2087029089 abstract "Abstract The effect of the phenothiazines, thioridazine and chlorpromazine, on the increased hepatic NAD+ level of rats fed clofibrate, a hypolipidaemic drug, has been investigated. Short-term (6 days) addition of phenothiazines to the diet negatively affected diet intake and body-weight gain, but increased liver weight and hepatic NAD+ levels, which was synergistic to clofibrate. The phenothiazines were shown to inhibit hepatic peroxisomal fatty acid oxidation in-vivo, as determined by the increased residual catalase activity. In hepatocytes prepared from clofibrate-fed rats, phenothiazines inhibited not only peroxisomal but also mitochondrial fatty acid oxidation to the same extent. In the hepatocytes, NAD+ was maintained at the high level until the phenothiazine concentration was increased to 0–2 mM. The result suggests that the increase of hepatic NAD+ in rats fed Clofibrate is not related to peroxisomal fatty acid oxidation." @default.
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• W2087029089 date "1998-04-01" @default.
• W2087029089 modified "2023-09-24" @default.
• W2087029089 title "Effect of Thioridazine or Chlorpromazine on Increased Hepatic NAD+ Level in Rats Fed Clofibrate, a Hypolipidaemic Drug" @default.
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• W2087029089 doi "https://doi.org/10.1111/j.2042-7158.1998.tb06884.x" @default.
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