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• W2088894479 endingPage "6442" @default.
• W2088894479 startingPage "6430" @default.
• W2088894479 abstract "Complex gene regulatory circuits contain many features that are likely to contribute to their operation. It is unclear, however, whether all these features are necessary for proper circuit behavior or whether certain ones are refinements that make the circuit work better but are dispensable for qualitatively normal behavior. We have addressed this question using the phage lambda regulatory circuit, which can persist in two stable states, the lytic state and the lysogenic state. In the lysogenic state, the CI repressor positively regulates its own expression by stimulating transcription from the P(RM) promoter. We tested whether this feature is an essential part of the regulatory circuitry. Several phages with a cI mutation preventing positive autoregulation and an up mutation in the P(RM) promoter showed near-normal behavior. We conclude that positive autoregulation is not necessary for proper operation of the lambda circuitry and speculate that it serves a partially redundant function of stabilizing a bistable circuit, a form of redundancy we term circuit-level redundancy. We discuss our findings in the context of a two-stage model for evolution and elaboration of regulatory circuits from simpler to more complex forms." @default.
• W2088894479 created "2016-06-24" @default.
• W2088894479 creator A5018548788 @default.
• W2088894479 creator A5091797099 @default.
• W2088894479 date "2005-09-15" @default.
• W2088894479 modified "2023-10-17" @default.
• W2088894479 title "Positive Autoregulation of <i>c</i> I Is a Dispensable Feature of the Phage λ Gene Regulatory Circuitry" @default.
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• W2088894479 doi "https://doi.org/10.1128/jb.187.18.6430-6442.2005" @default.
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