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• W2091794239 abstract "Sodium salts are potent taste stimuli, but their effectiveness is markedly dependent on the anion, with chloride yielding the greatest response. The cellular mechanisms that mediate this phenomenon are not known. This anion paradox has been resolved by considering the field potential that is generated by restricted electrodiffusion of the anion through paracellular shunts between taste-bud cells. Neural responses to sodium chloride, sodium acetate, and sodium gluconate were studied while the field potential was voltage-clamped. Clamping at electronegative values eliminated the anion effect, whereas clamping at electropositive potentials exaggerated it. Thus, field potentials across the lingual epithelium modulate taste reception, indicating that the functional unit of taste reception includes the taste cell and its paracellular microenvironment." @default.
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• W2091794239 date "1991-11-01" @default.
• W2091794239 modified "2023-10-17" @default.
• W2091794239 title "The Anion Paradox in Sodium Taste Reception: Resolution by Voltage-Clamp Studies" @default.
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• W2091794239 doi "https://doi.org/10.1126/science.1948054" @default.
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