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- W2093978889 abstract "The pattern electroretinogram (PERG) has been previously shown to be sensitive to dopaminergic manipulations in the monkey's retina. In order to study the role of retinal D2 receptors were recorded the PERG before and during the acute administration of l-sulpiride, a selective D2 blocker, in three monkeys. The stimuli were sinusoidal vertical gratings, with a contrast of 70% counterphase modulated at 7.5 Hz. The response to four different spatial frequencies (0.5, 1.1, 2.3 and 4.6 c/deg) was explored. PERGs were recorded before and after 20 min of i.m. administration of l-sulpiride. Two different doses (0.07 and 0.35 mg/kg) were administered in different sessions for each spatial frequency (SF). Baseline (before sulpiride) responses showed high intersession reproducibility, with a clear SF tuning. Both doses of the drug affected the PERG to the peak SF of the stimulus, but the higher one was more consistently effective in all of the three monkeys. Our results confirm previous studies which suggested that DA is involved in retinal processing in the primate and reveal the new information that D2 receptors are necessary for spatio-temporal tuning of pattern vision." @default.
- W2093978889 created "2016-06-24" @default.
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- W2093978889 date "1994-08-01" @default.
- W2093978889 modified "2023-09-23" @default.
- W2093978889 title "Spatial frequency tuning of the monkey pattern erg depends on d2 receptor-linked action of dopamine" @default.
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- W2093978889 doi "https://doi.org/10.1016/0042-6989(94)90316-6" @default.
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