FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094471806> ?p ?o ?g. }

• W2094471806 endingPage "e20757" @default.
• W2094471806 startingPage "e20757" @default.
• W2094471806 abstract "We have previously identified the scaffold protein liprin-α1 as an important regulator of integrin-mediated cell motility and tumor cell invasion. Liprin-α1 may interact with different proteins, and the functional significance of these interactions in the regulation of cell motility is poorly known. Here we have addressed the involvement of the liprin-α1 partner GIT1 in liprin-α1-mediated effects on cell spreading and migration. GIT1 depletion inhibited spreading by affecting the lamellipodia, and prevented liprin-α1-enhanced spreading. Conversely inhibition of the formation of the liprin-α1-GIT complex by expression of liprin-ΔCC3 could still enhance spreading, although to a lesser extent compared to full length liprin-α1. No cumulative effects were observed after depletion of both liprin-α1 and GIT1, suggesting that the two proteins belong to the same signaling network in the regulation of cell spreading. Our data suggest that liprin-α1 may compete with paxillin for binding to GIT1, while binding of βPIX to GIT1 was unaffected by the presence of liprin-α1. Interestingly, GIT and liprin-α1 reciprocally regulated their subcellular localization, since liprin-α1 overexpression, but not the GIT binding-defective liprin-ΔCC3 mutant, affected the localization of endogenous GIT at peripheral and mature central focal adhesions, while the expression of a truncated, active form of GIT1 enhanced the localization of endogenous liprin-α1 at the edge of spreading cells. Moreover, GIT1 was required for liprin-α1-enhanced haptotatic migration, although the direct interaction between liprin-α1 and GIT1 was not needed. Our findings show that the functional interaction between liprin-α1 and GIT1 cooperate in the regulation of integrin-dependent cell spreading and motility on extracellular matrix. These findings and the possible competition of liprin-α1 with paxillin for binding to GIT1 suggest that alternative binding of GIT1 to either liprin-α1 or paxillin plays distinct roles in different phases of the protrusive activity in the cell." @default.
• W2094471806 created "2016-06-24" @default.
• W2094471806 creator A5012981876 @default.
• W2094471806 creator A5019099417 @default.
• W2094471806 creator A5035861443 @default.
• W2094471806 creator A5050971669 @default.
• W2094471806 creator A5075384838 @default.
• W2094471806 creator A5078087085 @default.
• W2094471806 date "2011-06-13" @default.
• W2094471806 modified "2023-09-27" @default.
• W2094471806 title "Biochemical and Functional Characterization of the Interaction between Liprin-α1 and GIT1: Implications for the Regulation of Cell Motility" @default.
• W2094471806 cites W1527739697 @default.
• W2094471806 cites W1826668344 @default.
• W2094471806 cites W1964024918 @default.
• W2094471806 cites W1977152640 @default.
• W2094471806 cites W1982247535 @default.
• W2094471806 cites W1984967137 @default.
• W2094471806 cites W1985560593 @default.
• W2094471806 cites W1986201152 @default.
• W2094471806 cites W1994680857 @default.
• W2094471806 cites W1999927544 @default.
• W2094471806 cites W2007857936 @default.
• W2094471806 cites W2008944625 @default.
• W2094471806 cites W2009693492 @default.
• W2094471806 cites W2010366812 @default.
• W2094471806 cites W2015012123 @default.
• W2094471806 cites W2044935554 @default.
• W2094471806 cites W2048209624 @default.
• W2094471806 cites W2050106278 @default.
• W2094471806 cites W2061006256 @default.
• W2094471806 cites W2074495052 @default.
• W2094471806 cites W2075210551 @default.
• W2094471806 cites W2078594804 @default.
• W2094471806 cites W2081781663 @default.
• W2094471806 cites W2083816377 @default.
• W2094471806 cites W2086012892 @default.
• W2094471806 cites W2086405676 @default.
• W2094471806 cites W2099497713 @default.
• W2094471806 cites W2105809801 @default.
• W2094471806 cites W2109137906 @default.
• W2094471806 cites W2111155760 @default.
• W2094471806 cites W2112119382 @default.
• W2094471806 cites W2116276425 @default.
• W2094471806 cites W2118098860 @default.
• W2094471806 cites W2126376309 @default.
• W2094471806 cites W2137565495 @default.
• W2094471806 cites W2152348521 @default.
• W2094471806 cites W2162614357 @default.
• W2094471806 cites W2163660564 @default.
• W2094471806 cites W2165381688 @default.
• W2094471806 cites W2169209199 @default.
• W2094471806 cites W2419141319 @default.
• W2094471806 doi "https://doi.org/10.1371/journal.pone.0020757" @default.
• W2094471806 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3113849" @default.
• W2094471806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21695141" @default.
• W2094471806 hasPublicationYear "2011" @default.
• W2094471806 type Work @default.
• W2094471806 sameAs 2094471806 @default.
• W2094471806 citedByCount "10" @default.
• W2094471806 countsByYear W20944718062012 @default.
• W2094471806 countsByYear W20944718062015 @default.
• W2094471806 countsByYear W20944718062016 @default.
• W2094471806 countsByYear W20944718062019 @default.
• W2094471806 countsByYear W20944718062021 @default.
• W2094471806 countsByYear W20944718062022 @default.
• W2094471806 crossrefType "journal-article" @default.
• W2094471806 hasAuthorship W2094471806A5012981876 @default.
• W2094471806 hasAuthorship W2094471806A5019099417 @default.
• W2094471806 hasAuthorship W2094471806A5035861443 @default.
• W2094471806 hasAuthorship W2094471806A5050971669 @default.
• W2094471806 hasAuthorship W2094471806A5075384838 @default.
• W2094471806 hasAuthorship W2094471806A5078087085 @default.
• W2094471806 hasBestOaLocation W20944718061 @default.
• W2094471806 hasConcept C109185818 @default.
• W2094471806 hasConcept C116581196 @default.
• W2094471806 hasConcept C137738243 @default.
• W2094471806 hasConcept C1491633281 @default.
• W2094471806 hasConcept C151166631 @default.
• W2094471806 hasConcept C53645450 @default.
• W2094471806 hasConcept C55493867 @default.
• W2094471806 hasConcept C58207958 @default.
• W2094471806 hasConcept C62478195 @default.
• W2094471806 hasConcept C86803240 @default.
• W2094471806 hasConcept C95444343 @default.
• W2094471806 hasConceptScore W2094471806C109185818 @default.
• W2094471806 hasConceptScore W2094471806C116581196 @default.
• W2094471806 hasConceptScore W2094471806C137738243 @default.
• W2094471806 hasConceptScore W2094471806C1491633281 @default.
• W2094471806 hasConceptScore W2094471806C151166631 @default.
• W2094471806 hasConceptScore W2094471806C53645450 @default.
• W2094471806 hasConceptScore W2094471806C55493867 @default.
• W2094471806 hasConceptScore W2094471806C58207958 @default.
• W2094471806 hasConceptScore W2094471806C62478195 @default.
• W2094471806 hasConceptScore W2094471806C86803240 @default.
• W2094471806 hasConceptScore W2094471806C95444343 @default.
• W2094471806 hasIssue "6" @default.
• W2094471806 hasLocation W20944718061 @default.
• W2094471806 hasLocation W20944718062 @default.

• next