Matches in SemOpenAlex for { <https://semopenalex.org/work/W2097029491> ?p ?o ?g. }
- W2097029491 endingPage "571" @default.
- W2097029491 startingPage "559" @default.
- W2097029491 abstract "We report a secreted serine protease inhibitor Kazal-type-like (SPINKL) protein. The SPINKL protein was purified from mouse seminal vesicle secretions through a series of steps, including ion-exchange chromatography on a diethylaminoethyl-Sephacel column, gel filtration on a Sephadex G-75 column, and ion-exchange HPLC on a Q strong anion exchange column. Further analysis identified several SPINKL proteins with various N-linked carbohydrates. The SPINKL protein has six conserved cysteine residues that are nearly identical to those of members of the SPINK protein family. It was noted that the SPINKL protein showed no inhibitory activities against common serine proteases such as trypsin, chymotrypsin, subtilisin, or elastase. Spinkl mRNA and SPINKL proteins were found to be primarily expressed in seminal vesicles. Immunohistochemistry revealed that the SPINKL protein occurred in the luminal fluid and mucosal epithelium of the seminal vesicles and was regulated by testosterone. The SPINKL protein was able to bind onto sperm and enhance sperm motility. Also, it was able to suppress BSA-stimulated sperm capacitation and block sperm-oocyte interactions in vitro, suggesting that SPINKL may be a decapacitation factor." @default.
- W2097029491 created "2016-06-24" @default.
- W2097029491 creator A5004734092 @default.
- W2097029491 creator A5032021356 @default.
- W2097029491 creator A5047020069 @default.
- W2097029491 creator A5073879766 @default.
- W2097029491 creator A5081385902 @default.
- W2097029491 creator A5084536845 @default.
- W2097029491 creator A5086041722 @default.
- W2097029491 creator A5091791405 @default.
- W2097029491 date "2008-11-01" @default.
- W2097029491 modified "2023-09-24" @default.
- W2097029491 title "SPINKL, a Kazal-type serine protease inhibitor-like protein purified from mouse seminal vesicle fluid, is able to inhibit sperm capacitation" @default.
- W2097029491 cites W1545190570 @default.
- W2097029491 cites W1870184698 @default.
- W2097029491 cites W1889574244 @default.
- W2097029491 cites W1922120593 @default.
- W2097029491 cites W1980838951 @default.
- W2097029491 cites W1980996405 @default.
- W2097029491 cites W1986790586 @default.
- W2097029491 cites W1992509386 @default.
- W2097029491 cites W2004065156 @default.
- W2097029491 cites W2007786095 @default.
- W2097029491 cites W2020359343 @default.
- W2097029491 cites W2021301114 @default.
- W2097029491 cites W2021357124 @default.
- W2097029491 cites W2022488752 @default.
- W2097029491 cites W2025945521 @default.
- W2097029491 cites W2029541880 @default.
- W2097029491 cites W2029831063 @default.
- W2097029491 cites W2054591844 @default.
- W2097029491 cites W2071378754 @default.
- W2097029491 cites W2072825340 @default.
- W2097029491 cites W2073750894 @default.
- W2097029491 cites W2095581618 @default.
- W2097029491 cites W2101108802 @default.
- W2097029491 cites W2107213706 @default.
- W2097029491 cites W2109086273 @default.
- W2097029491 cites W2110744500 @default.
- W2097029491 cites W2123675273 @default.
- W2097029491 cites W2127840402 @default.
- W2097029491 cites W2137955622 @default.
- W2097029491 cites W2140422547 @default.
- W2097029491 cites W2153550523 @default.
- W2097029491 cites W2156359843 @default.
- W2097029491 cites W2161056239 @default.
- W2097029491 cites W2162520402 @default.
- W2097029491 cites W2165616399 @default.
- W2097029491 cites W2167408220 @default.
- W2097029491 cites W2198964118 @default.
- W2097029491 cites W2344048531 @default.
- W2097029491 cites W29790671 @default.
- W2097029491 cites W4232534952 @default.
- W2097029491 cites W4255410174 @default.
- W2097029491 doi "https://doi.org/10.1530/rep-07-0375" @default.
- W2097029491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18715980" @default.
- W2097029491 hasPublicationYear "2008" @default.
- W2097029491 type Work @default.
- W2097029491 sameAs 2097029491 @default.
- W2097029491 citedByCount "41" @default.
- W2097029491 countsByYear W20970294912012 @default.
- W2097029491 countsByYear W20970294912013 @default.
- W2097029491 countsByYear W20970294912015 @default.
- W2097029491 countsByYear W20970294912016 @default.
- W2097029491 countsByYear W20970294912017 @default.
- W2097029491 countsByYear W20970294912018 @default.
- W2097029491 countsByYear W20970294912019 @default.
- W2097029491 countsByYear W20970294912020 @default.
- W2097029491 countsByYear W20970294912021 @default.
- W2097029491 countsByYear W20970294912022 @default.
- W2097029491 crossrefType "journal-article" @default.
- W2097029491 hasAuthorship W2097029491A5004734092 @default.
- W2097029491 hasAuthorship W2097029491A5032021356 @default.
- W2097029491 hasAuthorship W2097029491A5047020069 @default.
- W2097029491 hasAuthorship W2097029491A5073879766 @default.
- W2097029491 hasAuthorship W2097029491A5081385902 @default.
- W2097029491 hasAuthorship W2097029491A5084536845 @default.
- W2097029491 hasAuthorship W2097029491A5086041722 @default.
- W2097029491 hasAuthorship W2097029491A5091791405 @default.
- W2097029491 hasBestOaLocation W20970294911 @default.
- W2097029491 hasConcept C121608353 @default.
- W2097029491 hasConcept C153911025 @default.
- W2097029491 hasConcept C163994747 @default.
- W2097029491 hasConcept C181199279 @default.
- W2097029491 hasConcept C182220744 @default.
- W2097029491 hasConcept C185592680 @default.
- W2097029491 hasConcept C202751555 @default.
- W2097029491 hasConcept C2776235491 @default.
- W2097029491 hasConcept C2776414213 @default.
- W2097029491 hasConcept C2776714187 @default.
- W2097029491 hasConcept C2777632594 @default.
- W2097029491 hasConcept C2777807008 @default.
- W2097029491 hasConcept C2778401398 @default.
- W2097029491 hasConcept C2779811187 @default.
- W2097029491 hasConcept C2780301668 @default.
- W2097029491 hasConcept C2780340462 @default.
- W2097029491 hasConcept C2781087480 @default.
- W2097029491 hasConcept C2781171107 @default.