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• W2100039188 abstract "The ErbB2/3 heterodimer plays a critical role in breast cancer genesis and progression. EBP1, an ErbB3 binding protein, inhibits breast cancer growth but its effects on ErbB3 ligand mediated signal transduction or ErbB receptors is not known. We report here that ectopic expression of EBP1 in MCF-7 and AU565 breast cancer cell lines inhibited HRG-induced proliferation. ErbB2 protein levels were substantially decreased in EBP1 transfectants, while ErbB3 levels were unchanged. HRG-induced AKT activation was attenuated in EBP1 stable transfectants and transfection of a constitutively activated AKT partially restored the growth response to HRG. Down-regulation of EBP1 expression in MCF-7 cells by shRNA resulted in increased cell growth in response to HRG and increased cyclin D1 and ErbB2 expression. These results suggest that EBP1, by down-regulating ErbB signal transduction, attentuates HRG-mediated growth of breast cancer cells." @default.
• W2100039188 created "2016-06-24" @default.
• W2100039188 creator A5054907108 @default.
• W2100039188 creator A5058620859 @default.
• W2100039188 creator A5059563321 @default.
• W2100039188 date "2008-07-01" @default.
• W2100039188 modified "2023-10-17" @default.
• W2100039188 title "Inhibition of heregulin mediated MCF-7 breast cancer cell growth by the ErbB3 binding protein EBP1" @default.
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• W2100039188 doi "https://doi.org/10.1016/j.canlet.2008.02.024" @default.
• W2100039188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2464455" @default.
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• W2100039188 hasPublicationYear "2008" @default.
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