FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100040188> ?p ?o ?g. }

• W2100040188 endingPage "382" @default.
• W2100040188 startingPage "371" @default.
• W2100040188 abstract "Caenorhabditis elegans body wall muscle contains two isoforms of myosin heavy chain, MHC A and MHC B, that differ in their ability to initiate thick filament assembly. Whereas mutant animals that lack the major isoform, MHC B, have fewer thick filaments, mutant animals that lack the minor isoform, MHC A, contain no normal thick filaments. MHC A, but not MHC B, is present at the center of the bipolar thick filament where initiation of assembly is thought to occur (Miller, D.M.,I. Ortiz, G.C. Berliner, and H.F. Epstein. 1983. Cell. 34:477-490). We mapped the sequences that confer A-specific function by constructing chimeric myosins and testing them in vivo. We have identified two distinct regions of the MHC A rod that are sufficient in chimeric myosins for filament initiation function. Within these regions, MHC A displays a more hydrophobic rod surface, making it more similar to paramyosin, which forms the thick filament core. We propose that these regions play an important role in filament initiation, perhaps mediating close contacts between MHC A and paramyosin in an antiparallel arrangement at the filament center. Furthermore, our analysis revealed that all striated muscle myosins show a characteristic variation in surface hydrophobicity along the length of the rod that may play an important role in driving assembly and determining the stagger at which dimers associate." @default.
• W2100040188 created "2016-06-24" @default.
• W2100040188 creator A5006493862 @default.
• W2100040188 creator A5074206499 @default.
• W2100040188 date "1996-10-15" @default.
• W2100040188 modified "2023-09-26" @default.
• W2100040188 title "Hydrophobicity variations along the surface of the coiled-coil rod may mediate striated muscle myosin assembly in Caenorhabditis elegans." @default.
• W2100040188 cites W106780798 @default.
• W2100040188 cites W1484816165 @default.
• W2100040188 cites W1485162707 @default.
• W2100040188 cites W1520468740 @default.
• W2100040188 cites W1540034139 @default.
• W2100040188 cites W1601082571 @default.
• W2100040188 cites W1742670372 @default.
• W2100040188 cites W1847602617 @default.
• W2100040188 cites W1933141659 @default.
• W2100040188 cites W1944127002 @default.
• W2100040188 cites W1964359164 @default.
• W2100040188 cites W1975289346 @default.
• W2100040188 cites W1975304761 @default.
• W2100040188 cites W1976487383 @default.
• W2100040188 cites W1979175552 @default.
• W2100040188 cites W1980581336 @default.
• W2100040188 cites W1998591058 @default.
• W2100040188 cites W2002837417 @default.
• W2100040188 cites W2006085462 @default.
• W2100040188 cites W2007281054 @default.
• W2100040188 cites W2015650126 @default.
• W2100040188 cites W2033028307 @default.
• W2100040188 cites W2039839088 @default.
• W2100040188 cites W2045841038 @default.
• W2100040188 cites W2048380590 @default.
• W2100040188 cites W2048660659 @default.
• W2100040188 cites W2050273382 @default.
• W2100040188 cites W2051757558 @default.
• W2100040188 cites W2064272399 @default.
• W2100040188 cites W2071229616 @default.
• W2100040188 cites W2096853306 @default.
• W2100040188 cites W2107955530 @default.
• W2100040188 cites W2120366711 @default.
• W2100040188 cites W2122163057 @default.
• W2100040188 cites W2123476288 @default.
• W2100040188 cites W2144112248 @default.
• W2100040188 cites W2150192655 @default.
• W2100040188 cites W2152427924 @default.
• W2100040188 cites W2168582728 @default.
• W2100040188 cites W2172335639 @default.
• W2100040188 cites W2292452512 @default.
• W2100040188 cites W2888511473 @default.
• W2100040188 cites W4234290082 @default.
• W2100040188 doi "https://doi.org/10.1083/jcb.135.2.371" @default.
• W2100040188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2121044" @default.
• W2100040188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8896595" @default.
• W2100040188 hasPublicationYear "1996" @default.
• W2100040188 type Work @default.
• W2100040188 sameAs 2100040188 @default.
• W2100040188 citedByCount "38" @default.
• W2100040188 countsByYear W21000401882012 @default.
• W2100040188 countsByYear W21000401882013 @default.
• W2100040188 countsByYear W21000401882017 @default.
• W2100040188 countsByYear W21000401882018 @default.
• W2100040188 countsByYear W21000401882020 @default.
• W2100040188 countsByYear W21000401882022 @default.
• W2100040188 crossrefType "journal-article" @default.
• W2100040188 hasAuthorship W2100040188A5006493862 @default.
• W2100040188 hasAuthorship W2100040188A5074206499 @default.
• W2100040188 hasBestOaLocation W21000401881 @default.
• W2100040188 hasConcept C104317684 @default.
• W2100040188 hasConcept C115260700 @default.
• W2100040188 hasConcept C121332964 @default.
• W2100040188 hasConcept C12554922 @default.
• W2100040188 hasConcept C142089489 @default.
• W2100040188 hasConcept C14228908 @default.
• W2100040188 hasConcept C142669718 @default.
• W2100040188 hasConcept C143065580 @default.
• W2100040188 hasConcept C1491633281 @default.
• W2100040188 hasConcept C170627219 @default.
• W2100040188 hasConcept C207936829 @default.
• W2100040188 hasConcept C2778944004 @default.
• W2100040188 hasConcept C53345823 @default.
• W2100040188 hasConcept C54355233 @default.
• W2100040188 hasConcept C55493867 @default.
• W2100040188 hasConcept C55988834 @default.
• W2100040188 hasConcept C62520636 @default.
• W2100040188 hasConcept C6997183 @default.
• W2100040188 hasConcept C78383274 @default.
• W2100040188 hasConcept C86803240 @default.
• W2100040188 hasConcept C8891405 @default.
• W2100040188 hasConcept C95444343 @default.
• W2100040188 hasConceptScore W2100040188C104317684 @default.
• W2100040188 hasConceptScore W2100040188C115260700 @default.
• W2100040188 hasConceptScore W2100040188C121332964 @default.
• W2100040188 hasConceptScore W2100040188C12554922 @default.
• W2100040188 hasConceptScore W2100040188C142089489 @default.
• W2100040188 hasConceptScore W2100040188C14228908 @default.
• W2100040188 hasConceptScore W2100040188C142669718 @default.
• W2100040188 hasConceptScore W2100040188C143065580 @default.
• W2100040188 hasConceptScore W2100040188C1491633281 @default.

• next