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- W2100065014 abstract "Risk of “silent stroke” in patients older than 60 years: risk assessment and clinical perspectives Jae-Sung Lim1, Hyung-Min Kwon21Department of Neurology, Armed Forces Seoul Hospital, Seoul, Republic of Korea; 2Department of Neurology, Seoul National University Boramae Hospital, Seoul, Republic of KoreaAbstract: With the increasing size of the elderly population and evolving imaging technology, silent brain infarction (SBI) has garnered attention from both the public and the physicians. Over 20% of the elderly exhibit SBI, and the prevalence of SBI increases steadily with age, ie, 30%–40% in those older than 70 years. Well-known cardiovascular risk factors such as hypertension has been identified as a risk factor of SBI (odds ratio [OR] = 3.47) Besides this, blood pressure (BP) reactivity to mental stress, morning BP surges, and orthostatic BP changes have been demonstrated to contribute to the presence of SBI. Further, a metabolic syndrome not only as a whole syndrome (OR = 2.18) but also as individual components could have an influence on SBI. Increased C-reactive protein and interleukin-6, coronary artery disease, body mass index, and alcohol consumption have also been associated with SBI. The ORs and possible mechanisms have been discussed in this article. Overt stroke, dementia, depression, and aspiration pneumonia were all associated with SBI. (overt stroke: hazard ratio [HR] = 1.9, 95% confidence interval [CI]; 1.2–2.8; dementia: HR = 2.26, 95% CI: 1.09–4.70). We also looked into their close relationship with SBI in this review.Keywords: silent brain infarction, elderly, risk factors, treatment" @default.
- W2100065014 created "2016-06-24" @default.
- W2100065014 creator A5020431565 @default.
- W2100065014 creator A5086195230 @default.
- W2100065014 date "2010-09-01" @default.
- W2100065014 modified "2023-10-16" @default.
- W2100065014 title "Risk of “silent stroke” in patients older than 60 years: risk assessment and clinical perspectives" @default.
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- W2100065014 doi "https://doi.org/10.2147/cia.s7382" @default.
- W2100065014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2938031" @default.
- W2100065014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20852671" @default.
- W2100065014 hasPublicationYear "2010" @default.
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