FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100065646> ?p ?o ?g. }

• W2100065646 endingPage "180" @default.
• W2100065646 startingPage "180" @default.
• W2100065646 abstract "Clinical events committees (CEC) are used routinely to adjudicate suspected end-points in cardiovascular trials, but little information has been published about the various processes used. We reviewed results of the CEC process used to identify and adjudicate suspected end-point (post-enrolment) myocardial infarction (MI) in the large Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin (Eptifibatide) Therapy (PURSUIT) trial. The PURSUIT trial randomised 10,948 patients with acute coronary syndromes to receive eptifibatide or placebo. A central adjudication process was established prospectively to identify all suspected MIs and adjudicate events based on protocol definitions of MI. Suspected MIs were identified by systematic review of data collection forms, cardiac enzyme results, and electrocardiograms. Two physicians independently reviewed all suspected events. If they disagreed whether a MI had occurred, a committee of cardiologists adjudicated the case. The CEC identified 5005 patients with suspected infarction (46%), of which 1415 (28%) were adjudicated as end-point infarctions. As expected, the process identified more end-point events than did the site investigators. Absolute and relative treatment effects of eptifibatide were smaller when using CEC-determined MI rates rather than site investigator-determined rates. The site-investigator reporting of MI and the CEC assessment of MI disagreed in 20% of the cases reviewed by the CEC. End-point adjudication by a CEC is important, to provide standardised, systematic, independent, and unbiased assessment of end-points, particularly in trials that span geographic regions and clinical practice settings. Understanding the CEC process used is important in the interpretation of trial results and event rates." @default.
• W2100065646 created "2016-06-24" @default.
• W2100065646 creator A5004104973 @default.
• W2100065646 creator A5014449865 @default.
• W2100065646 creator A5015610233 @default.
• W2100065646 creator A5029768994 @default.
• W2100065646 creator A5032084935 @default.
• W2100065646 creator A5039432822 @default.
• W2100065646 creator A5039754301 @default.
• W2100065646 creator A5044667077 @default.
• W2100065646 creator A5047661952 @default.
• W2100065646 creator A5049171708 @default.
• W2100065646 creator A5050815940 @default.
• W2100065646 creator A5060370891 @default.
• W2100065646 creator A5060829829 @default.
• W2100065646 creator A5079156387 @default.
• W2100065646 creator A5080668571 @default.
• W2100065646 creator A5087516645 @default.
• W2100065646 creator A5090025228 @default.
• W2100065646 date "2001-01-01" @default.
• W2100065646 modified "2023-09-26" @default.
• W2100065646 cites W1596397105 @default.
• W2100065646 cites W1988335534 @default.
• W2100065646 cites W2010280774 @default.
• W2100065646 cites W2023779739 @default.
• W2100065646 cites W2026202162 @default.
• W2100065646 cites W2035210831 @default.
• W2100065646 cites W2063131612 @default.
• W2100065646 cites W2065624329 @default.
• W2100065646 cites W2073743496 @default.
• W2100065646 cites W2078113728 @default.
• W2100065646 cites W2116738159 @default.
• W2100065646 cites W2230838014 @default.
• W2100065646 cites W2312388685 @default.
• W2100065646 cites W2313726388 @default.
• W2100065646 cites W2332843202 @default.
• W2100065646 cites W2395313915 @default.
• W2100065646 cites W2527032421 @default.
• W2100065646 cites W2537589444 @default.
• W2100065646 cites W3022148767 @default.
• W2100065646 cites W4231431115 @default.
• W2100065646 cites W4237482550 @default.
• W2100065646 cites W4237892021 @default.
• W2100065646 cites W4256202725 @default.
• W2100065646 cites W4290747706 @default.
• W2100065646 cites W4299614816 @default.
• W2100065646 cites W4300813692 @default.
• W2100065646 doi "https://doi.org/10.1186/cvm-2-4-180" @default.
• W2100065646 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/57749" @default.
• W2100065646 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11806793" @default.
• W2100065646 hasPublicationYear "2001" @default.
• W2100065646 type Work @default.
• W2100065646 sameAs 2100065646 @default.
• W2100065646 citedByCount "69" @default.
• W2100065646 countsByYear W21000656462012 @default.
• W2100065646 countsByYear W21000656462013 @default.
• W2100065646 countsByYear W21000656462014 @default.
• W2100065646 countsByYear W21000656462015 @default.
• W2100065646 countsByYear W21000656462016 @default.
• W2100065646 countsByYear W21000656462017 @default.
• W2100065646 countsByYear W21000656462018 @default.
• W2100065646 countsByYear W21000656462019 @default.
• W2100065646 countsByYear W21000656462020 @default.
• W2100065646 countsByYear W21000656462021 @default.
• W2100065646 countsByYear W21000656462022 @default.
• W2100065646 crossrefType "journal-article" @default.
• W2100065646 hasAuthorship W2100065646A5004104973 @default.
• W2100065646 hasAuthorship W2100065646A5014449865 @default.
• W2100065646 hasAuthorship W2100065646A5015610233 @default.
• W2100065646 hasAuthorship W2100065646A5029768994 @default.
• W2100065646 hasAuthorship W2100065646A5032084935 @default.
• W2100065646 hasAuthorship W2100065646A5039432822 @default.
• W2100065646 hasAuthorship W2100065646A5039754301 @default.
• W2100065646 hasAuthorship W2100065646A5044667077 @default.
• W2100065646 hasAuthorship W2100065646A5047661952 @default.
• W2100065646 hasAuthorship W2100065646A5049171708 @default.
• W2100065646 hasAuthorship W2100065646A5050815940 @default.
• W2100065646 hasAuthorship W2100065646A5060370891 @default.
• W2100065646 hasAuthorship W2100065646A5060829829 @default.
• W2100065646 hasAuthorship W2100065646A5079156387 @default.
• W2100065646 hasAuthorship W2100065646A5080668571 @default.
• W2100065646 hasAuthorship W2100065646A5087516645 @default.
• W2100065646 hasAuthorship W2100065646A5090025228 @default.
• W2100065646 hasBestOaLocation W21000656461 @default.
• W2100065646 hasConcept C126322002 @default.
• W2100065646 hasConcept C164705383 @default.
• W2100065646 hasConcept C17744445 @default.
• W2100065646 hasConcept C199539241 @default.
• W2100065646 hasConcept C203092338 @default.
• W2100065646 hasConcept C204434341 @default.
• W2100065646 hasConcept C2777698277 @default.
• W2100065646 hasConcept C2777785093 @default.
• W2100065646 hasConcept C2780400711 @default.
• W2100065646 hasConcept C2781056559 @default.
• W2100065646 hasConcept C500558357 @default.
• W2100065646 hasConcept C535046627 @default.
• W2100065646 hasConcept C71924100 @default.
• W2100065646 hasConceptScore W2100065646C126322002 @default.

• next