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- W2100084025 abstract "MicroiRNAs are genome encoded small double stranded RNAs that regulate expression of homologous mRNAs. With approximately 2500 human miRNAs and each having hundreds of potential mRNA targets, miRNA based gene regulation is quite pervasive in both development and disease. While there are numerous studies investigating miRNA:mRNA and miRNA:protein target expression correlations, there are relatively few studies of miRNA:miRNA co-expression. Here we report on our analysis of miRNA:miRNA co-expression using expression data from the miRNA expression atlas of Landgraf et al. Our analysis indicates that many, but not all, genomically clustered miRNAs are co-expressed as a single pri-miRNA transcript. We have also identified co-expression groups that have similar biological activity. Further, the non-correlative miRNAs we have uncovered have been shown to be of utility in establishing miRNA biomarkers and signatures for certain tumours and cancers." @default.
- W2100084025 created "2016-06-24" @default.
- W2100084025 creator A5026963517 @default.
- W2100084025 creator A5054449714 @default.
- W2100084025 creator A5055662027 @default.
- W2100084025 date "2016-01-01" @default.
- W2100084025 modified "2023-10-09" @default.
- W2100084025 title "Correlations of microRNA:microRNA expression patterns reveal insights into microRNA clusters and global microRNA expression patterns" @default.
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- W2100084025 doi "https://doi.org/10.1039/c5mb00415b" @default.
- W2100084025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26563430" @default.
- W2100084025 hasPublicationYear "2016" @default.
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