FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100085836> ?p ?o ?g. }

• W2100085836 endingPage "8786" @default.
• W2100085836 startingPage "8778" @default.
• W2100085836 abstract "ABSTRACT MicroRNAs (miRNAs) are a class of small (∼22-nucleotide) regulatory molecules that block translation or induce degradation of target mRNAs. These have been identified in a wide range of organisms, including viruses. In particular, the oncogenic gammaherpesviruses Kaposi's sarcoma herpesvirus and Epstein-Barr virus encode miRNAs that could potentially regulate either viral or host genes. To determine if Marek's disease virus (MDV), an oncogenic alphaherpesvirus of chickens, encodes miRNAs, we isolated small RNAs from MDV-infected chicken embryo fibroblasts (CEF) and used the 454 Life Sciences sequencing technology to obtain the sequences of 13,679 candidate host and viral small RNAs. Eight miRNAs were found, five of which flank the meq oncogene and three that map to the latency-associated transcript (LAT) region of the genome. The meq gene is unique to pathogenic serotypes of MDV and is transcriptionally active during latency and transformation, and the LAT region of the MDV genome is antisense to the immediate-early gene ICP4. Secondary structure analysis predicted that the regions flanking the miRNAs could form hairpin precursors. Northern blot analysis confirmed expression of all miRNAs in MDV-infected CEF, MDV-induced tumors, and MDV lymphoblastoid cell lines. We propose that the MDV miRNAs function to enable MDV pathogenesis and contribute to MDV-induced transformation of chicken T cells." @default.
• W2100085836 created "2016-06-24" @default.
• W2100085836 creator A5001858374 @default.
• W2100085836 creator A5012770390 @default.
• W2100085836 creator A5014651704 @default.
• W2100085836 creator A5015350460 @default.
• W2100085836 creator A5023198608 @default.
• W2100085836 creator A5050264239 @default.
• W2100085836 creator A5053787652 @default.
• W2100085836 creator A5076526804 @default.
• W2100085836 creator A5080526872 @default.
• W2100085836 date "2006-09-01" @default.
• W2100085836 modified "2023-09-26" @default.
• W2100085836 title "Marek's Disease Virus Encodes MicroRNAs That Map to <i>meq</i> and the Latency-Associated Transcript" @default.
• W2100085836 cites W1485485237 @default.
• W2100085836 cites W1514566360 @default.
• W2100085836 cites W1542925727 @default.
• W2100085836 cites W1562585824 @default.
• W2100085836 cites W1661435486 @default.
• W2100085836 cites W1735266554 @default.
• W2100085836 cites W1752591280 @default.
• W2100085836 cites W1757498126 @default.
• W2100085836 cites W1812681386 @default.
• W2100085836 cites W1967007963 @default.
• W2100085836 cites W1980269624 @default.
• W2100085836 cites W1987491732 @default.
• W2100085836 cites W2002393523 @default.
• W2100085836 cites W2006623844 @default.
• W2100085836 cites W2020878700 @default.
• W2100085836 cites W2021606572 @default.
• W2100085836 cites W2030120875 @default.
• W2100085836 cites W2030489111 @default.
• W2100085836 cites W2031432943 @default.
• W2100085836 cites W2031531345 @default.
• W2100085836 cites W2031841357 @default.
• W2100085836 cites W2035317074 @default.
• W2100085836 cites W2038766179 @default.
• W2100085836 cites W2049187883 @default.
• W2100085836 cites W2050066317 @default.
• W2100085836 cites W2054266325 @default.
• W2100085836 cites W2062290101 @default.
• W2100085836 cites W2064389969 @default.
• W2100085836 cites W2064485169 @default.
• W2100085836 cites W2071596792 @default.
• W2100085836 cites W2075702234 @default.
• W2100085836 cites W2077488744 @default.
• W2100085836 cites W2078714758 @default.
• W2100085836 cites W2080407932 @default.
• W2100085836 cites W2081638813 @default.
• W2100085836 cites W2082213106 @default.
• W2100085836 cites W2083381199 @default.
• W2100085836 cites W2091070751 @default.
• W2100085836 cites W2095598434 @default.
• W2100085836 cites W2096894782 @default.
• W2100085836 cites W2106929712 @default.
• W2100085836 cites W2109739804 @default.
• W2100085836 cites W2111965996 @default.
• W2100085836 cites W2113869362 @default.
• W2100085836 cites W2117124710 @default.
• W2100085836 cites W2122211092 @default.
• W2100085836 cites W2123079914 @default.
• W2100085836 cites W2124842612 @default.
• W2100085836 cites W2125290827 @default.
• W2100085836 cites W2126732736 @default.
• W2100085836 cites W2127777510 @default.
• W2100085836 cites W2128114769 @default.
• W2100085836 cites W2130979840 @default.
• W2100085836 cites W2130993320 @default.
• W2100085836 cites W2135314242 @default.
• W2100085836 cites W2136715270 @default.
• W2100085836 cites W2138043022 @default.
• W2100085836 cites W2141157874 @default.
• W2100085836 cites W2146642335 @default.
• W2100085836 cites W2149385948 @default.
• W2100085836 cites W2150059352 @default.
• W2100085836 cites W2150536104 @default.
• W2100085836 cites W2150696691 @default.
• W2100085836 cites W2150770935 @default.
• W2100085836 cites W2151575991 @default.
• W2100085836 cites W2151922790 @default.
• W2100085836 cites W2152736091 @default.
• W2100085836 cites W2157039533 @default.
• W2100085836 cites W2158714788 @default.
• W2100085836 cites W2159767268 @default.
• W2100085836 cites W2167977613 @default.
• W2100085836 cites W2171230529 @default.
• W2100085836 cites W2186477130 @default.
• W2100085836 cites W2187745930 @default.
• W2100085836 cites W2233674177 @default.
• W2100085836 cites W2235639766 @default.
• W2100085836 cites W2239919420 @default.
• W2100085836 cites W2418122620 @default.
• W2100085836 cites W2419238671 @default.
• W2100085836 cites W4250385376 @default.
• W2100085836 doi "https://doi.org/10.1128/jvi.00831-06" @default.
• W2100085836 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1563840" @default.
• W2100085836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16912324" @default.
• W2100085836 hasPublicationYear "2006" @default.

• next