Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100092472> ?p ?o ?g. }
- W2100092472 endingPage "e53764" @default.
- W2100092472 startingPage "e53764" @default.
- W2100092472 abstract "Perhaps one of the most significant achievements in modern science is the discovery of human induced pluripotent stem cells (hiPSCs), which have paved the way for regeneration therapy using patients’ own cells. Cardiomyocytes differentiated from hiPSCs (hiPSC-CMs) could be used for modelling patients with heart failure, for testing new drugs, and for cellular therapy in the future. However, the present cardiomyocyte differentiation protocols exhibit variable differentiation efficiency across different hiPSC lines, which inhibit the application of this technology significantly. Here, we demonstrate a novel myocyte differentiation protocol that can yield a significant, high percentage of cardiac myocyte differentiation (>85%) in 2 hiPSC lines, which makes the fabrication of a human cardiac muscle patch possible. The established hiPSCs cell lines being examined include the transgene integrated UCBiPS7 derived from cord blood cells and non-integrated PCBC16iPS from skin fibroblasts. The results indicate that hiPSC-CMs derived from established hiPSC lines respond to adrenergic or acetylcholine stimulation and beat regularly for greater than 60 days. This data also demonstrates that this novel differentiation protocol can efficiently generate hiPSC-CMs from iPSC lines that are derived not only from fibroblasts, but also from blood mononuclear cells." @default.
- W2100092472 created "2016-06-24" @default.
- W2100092472 creator A5009439252 @default.
- W2100092472 creator A5024176882 @default.
- W2100092472 creator A5025147019 @default.
- W2100092472 creator A5030985040 @default.
- W2100092472 creator A5042070999 @default.
- W2100092472 creator A5055003008 @default.
- W2100092472 creator A5062734813 @default.
- W2100092472 creator A5077578379 @default.
- W2100092472 creator A5090065752 @default.
- W2100092472 date "2013-01-10" @default.
- W2100092472 modified "2023-10-17" @default.
- W2100092472 title "Effective Cardiac Myocyte Differentiation of Human Induced Pluripotent Stem Cells Requires VEGF" @default.
- W2100092472 cites W1972766500 @default.
- W2100092472 cites W1974009242 @default.
- W2100092472 cites W1977025496 @default.
- W2100092472 cites W1979342340 @default.
- W2100092472 cites W1985797014 @default.
- W2100092472 cites W1992525863 @default.
- W2100092472 cites W1996686879 @default.
- W2100092472 cites W2010417854 @default.
- W2100092472 cites W2018887952 @default.
- W2100092472 cites W2024122923 @default.
- W2100092472 cites W2031952260 @default.
- W2100092472 cites W2036521370 @default.
- W2100092472 cites W2039551265 @default.
- W2100092472 cites W2048107295 @default.
- W2100092472 cites W2049854021 @default.
- W2100092472 cites W2052002403 @default.
- W2100092472 cites W2053911973 @default.
- W2100092472 cites W2055162584 @default.
- W2100092472 cites W2070710140 @default.
- W2100092472 cites W2078286853 @default.
- W2100092472 cites W2081628067 @default.
- W2100092472 cites W2084201375 @default.
- W2100092472 cites W2091395040 @default.
- W2100092472 cites W2100761325 @default.
- W2100092472 cites W2102560467 @default.
- W2100092472 cites W2109720404 @default.
- W2100092472 cites W2125414211 @default.
- W2100092472 cites W2125987139 @default.
- W2100092472 cites W2132735690 @default.
- W2100092472 cites W2138977668 @default.
- W2100092472 cites W2142046859 @default.
- W2100092472 cites W2155291572 @default.
- W2100092472 cites W2158128644 @default.
- W2100092472 cites W2165368329 @default.
- W2100092472 cites W2166305181 @default.
- W2100092472 doi "https://doi.org/10.1371/journal.pone.0053764" @default.
- W2100092472 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3542360" @default.
- W2100092472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23326500" @default.
- W2100092472 hasPublicationYear "2013" @default.
- W2100092472 type Work @default.
- W2100092472 sameAs 2100092472 @default.
- W2100092472 citedByCount "57" @default.
- W2100092472 countsByYear W21000924722013 @default.
- W2100092472 countsByYear W21000924722014 @default.
- W2100092472 countsByYear W21000924722015 @default.
- W2100092472 countsByYear W21000924722016 @default.
- W2100092472 countsByYear W21000924722017 @default.
- W2100092472 countsByYear W21000924722018 @default.
- W2100092472 countsByYear W21000924722019 @default.
- W2100092472 countsByYear W21000924722020 @default.
- W2100092472 countsByYear W21000924722021 @default.
- W2100092472 countsByYear W21000924722022 @default.
- W2100092472 countsByYear W21000924722023 @default.
- W2100092472 crossrefType "journal-article" @default.
- W2100092472 hasAuthorship W2100092472A5009439252 @default.
- W2100092472 hasAuthorship W2100092472A5024176882 @default.
- W2100092472 hasAuthorship W2100092472A5025147019 @default.
- W2100092472 hasAuthorship W2100092472A5030985040 @default.
- W2100092472 hasAuthorship W2100092472A5042070999 @default.
- W2100092472 hasAuthorship W2100092472A5055003008 @default.
- W2100092472 hasAuthorship W2100092472A5062734813 @default.
- W2100092472 hasAuthorship W2100092472A5077578379 @default.
- W2100092472 hasAuthorship W2100092472A5090065752 @default.
- W2100092472 hasBestOaLocation W21000924721 @default.
- W2100092472 hasConcept C104317684 @default.
- W2100092472 hasConcept C107459253 @default.
- W2100092472 hasConcept C10854531 @default.
- W2100092472 hasConcept C10882517 @default.
- W2100092472 hasConcept C145103041 @default.
- W2100092472 hasConcept C148738053 @default.
- W2100092472 hasConcept C207200792 @default.
- W2100092472 hasConcept C28328180 @default.
- W2100092472 hasConcept C2910924664 @default.
- W2100092472 hasConcept C3018686881 @default.
- W2100092472 hasConcept C54355233 @default.
- W2100092472 hasConcept C81885089 @default.
- W2100092472 hasConcept C86803240 @default.
- W2100092472 hasConcept C95444343 @default.
- W2100092472 hasConceptScore W2100092472C104317684 @default.
- W2100092472 hasConceptScore W2100092472C107459253 @default.
- W2100092472 hasConceptScore W2100092472C10854531 @default.
- W2100092472 hasConceptScore W2100092472C10882517 @default.
- W2100092472 hasConceptScore W2100092472C145103041 @default.
- W2100092472 hasConceptScore W2100092472C148738053 @default.