FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100093357> ?p ?o ?g. }

• W2100093357 endingPage "1088" @default.
• W2100093357 startingPage "1081" @default.
• W2100093357 abstract "First-line epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) is a standard treatment for patients with activating EGFR mutations. Six randomized studies have demonstrated consistent improvement in tumor response rate and progression-free survival over platinum-based combination chemotherapy. The only reason to consider EGFR TKI as second-line therapy is that none of the six comparative studies has shown improvement in overall survival, which can be explained by the high proportion of patients from the chemotherapy arm crossing over to the EGFR TKI arm on progression. It is true that patients with EGFR mutations may benefit from second-line EGFR TKI therapy, but we cannot conclude that the benefit is either equal to or inferior to first-line EGFR TKI therapy. To date, there are no direct comparative data between first- and second-line EGFR TKI in patients with activating EGFR mutations. Tumor response rates to second-line EGFR TKI have been inconsistent, which could potentially be explained by the impact of first-line chemotherapy on the abundance of tumor cells with activating EGFR mutations. However, numerous arguments, including assurance on drug exposure, improvement in quality of life, better tolerance by patients with poor performance status, and deferral of whole-brain radiation therapy for patients with brain metastasis, support the general application of first-line EGFR TKI." @default.
• W2100093357 created "2016-06-24" @default.
• W2100093357 creator A5046604568 @default.
• W2100093357 creator A5056497965 @default.
• W2100093357 creator A5066717752 @default.
• W2100093357 date "2013-03-10" @default.
• W2100093357 modified "2023-10-14" @default.
• W2100093357 title "Treating Patients With EGFR-Sensitizing Mutations: First Line or Second Line—Is There a Difference?" @default.
• W2100093357 cites W1510465714 @default.
• W2100093357 cites W1970476748 @default.
• W2100093357 cites W1973817016 @default.
• W2100093357 cites W1999896690 @default.
• W2100093357 cites W2003764732 @default.
• W2100093357 cites W2005529809 @default.
• W2100093357 cites W2016717983 @default.
• W2100093357 cites W2030883899 @default.
• W2100093357 cites W2035406234 @default.
• W2100093357 cites W2036007569 @default.
• W2100093357 cites W2040181388 @default.
• W2100093357 cites W2041436152 @default.
• W2100093357 cites W2043587877 @default.
• W2100093357 cites W2043696829 @default.
• W2100093357 cites W2064989610 @default.
• W2100093357 cites W2069312070 @default.
• W2100093357 cites W2070121229 @default.
• W2100093357 cites W2078763461 @default.
• W2100093357 cites W2093614047 @default.
• W2100093357 cites W2095618958 @default.
• W2100093357 cites W2104748005 @default.
• W2100093357 cites W2104874286 @default.
• W2100093357 cites W2106297623 @default.
• W2100093357 cites W2107304950 @default.
• W2100093357 cites W2111191667 @default.
• W2100093357 cites W2111662961 @default.
• W2100093357 cites W2115091425 @default.
• W2100093357 cites W2116827288 @default.
• W2100093357 cites W2122890773 @default.
• W2100093357 cites W2124729820 @default.
• W2100093357 cites W2129360604 @default.
• W2100093357 cites W2132157071 @default.
• W2100093357 cites W2134897113 @default.
• W2100093357 cites W2135192471 @default.
• W2100093357 cites W2135595269 @default.
• W2100093357 cites W2137009016 @default.
• W2100093357 cites W2137510882 @default.
• W2100093357 cites W2139343412 @default.
• W2100093357 cites W2140775102 @default.
• W2100093357 cites W2142464801 @default.
• W2100093357 cites W2151522757 @default.
• W2100093357 cites W2154662831 @default.
• W2100093357 cites W2160982674 @default.
• W2100093357 cites W2161821474 @default.
• W2100093357 cites W2166084034 @default.
• W2100093357 cites W2168856723 @default.
• W2100093357 cites W2465149354 @default.
• W2100093357 cites W2590753874 @default.
• W2100093357 cites W2590757889 @default.
• W2100093357 cites W2591142400 @default.
• W2100093357 cites W2607182122 @default.
• W2100093357 cites W3012119175 @default.
• W2100093357 cites W3108750466 @default.
• W2100093357 doi "https://doi.org/10.1200/jco.2012.43.0652" @default.
• W2100093357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23401448" @default.
• W2100093357 hasPublicationYear "2013" @default.
• W2100093357 type Work @default.
• W2100093357 sameAs 2100093357 @default.
• W2100093357 citedByCount "92" @default.
• W2100093357 countsByYear W21000933572013 @default.
• W2100093357 countsByYear W21000933572014 @default.
• W2100093357 countsByYear W21000933572015 @default.
• W2100093357 countsByYear W21000933572016 @default.
• W2100093357 countsByYear W21000933572017 @default.
• W2100093357 countsByYear W21000933572018 @default.
• W2100093357 countsByYear W21000933572019 @default.
• W2100093357 countsByYear W21000933572020 @default.
• W2100093357 countsByYear W21000933572021 @default.
• W2100093357 countsByYear W21000933572022 @default.
• W2100093357 countsByYear W21000933572023 @default.
• W2100093357 crossrefType "journal-article" @default.
• W2100093357 hasAuthorship W2100093357A5046604568 @default.
• W2100093357 hasAuthorship W2100093357A5056497965 @default.
• W2100093357 hasAuthorship W2100093357A5066717752 @default.
• W2100093357 hasConcept C121608353 @default.
• W2100093357 hasConcept C126322002 @default.
• W2100093357 hasConcept C143998085 @default.
• W2100093357 hasConcept C2776694085 @default.
• W2100093357 hasConcept C2778087573 @default.
• W2100093357 hasConcept C2778820342 @default.
• W2100093357 hasConcept C2779438470 @default.
• W2100093357 hasConcept C2780739268 @default.
• W2100093357 hasConcept C71924100 @default.
• W2100093357 hasConceptScore W2100093357C121608353 @default.
• W2100093357 hasConceptScore W2100093357C126322002 @default.
• W2100093357 hasConceptScore W2100093357C143998085 @default.
• W2100093357 hasConceptScore W2100093357C2776694085 @default.
• W2100093357 hasConceptScore W2100093357C2778087573 @default.
• W2100093357 hasConceptScore W2100093357C2778820342 @default.
• W2100093357 hasConceptScore W2100093357C2779438470 @default.

• next