FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2100785280> ?p ?o ?g. }

• W2100785280 endingPage "33" @default.
• W2100785280 startingPage "33" @default.
• W2100785280 abstract "<h3>Background</h3> Genetic variants in immunomodulating genes have been suggested to contribute to the risk of cardiovascular disease. Glucocorticoids are important regulators of inflammatory processes and the immune system. Our aim was to determine the contribution of genetic glucocorticoid receptor variants, with different cortisol sensitivities, to the risk of cardiovascular disease. <h3>Methods</h3> The study was conducted in a large (n = 7983) population-based, prospective cohort of the Rotterdam Study. The mean duration of follow-up was 8.9 years. Measures of cardiovascular disease were incident myocardial infarction, coronary heart disease, high-sensitivity C-reactive protein level, interleukin 6 level, and arteria carotis intima-media thickness. <h3>Results</h3> Persons homozygous for haplotype 3, which is a common variant of the glucocorticoid receptor gene, had a more than 2-fold increased risk of myocardial infarction (hazard ratio, 2.1; 95% confidence interval, 1.13-4.07) and an almost 3-fold increased risk of coronary heart disease (hazard ratio, 2.6; 95% confidence interval, 1.40-4.81) compared with nonhomozygous persons. In addition, their C-reactive protein and interleukin 6 levels were higher, and carotis intima-media thickness was greater. No associations were found for the other haplotypes. <h3>Conclusions</h3> The glucocorticoid receptor gene haplotype 3 is a common genetic variant and is related to a more active proinflammatory system. This haplotype is associated with the risk of cardiovascular disease and its parameters. These results should be regarded as hypothesis generating until they have been replicated in other studies. Our findings suggest that genetically determined cortisol sensitivity is involved in the pathogenesis of cardiovascular disease and might identify a subgroup at risk." @default.
• W2100785280 created "2016-06-24" @default.
• W2100785280 creator A5004361068 @default.
• W2100785280 creator A5012841131 @default.
• W2100785280 creator A5031530236 @default.
• W2100785280 creator A5039611937 @default.
• W2100785280 creator A5046911852 @default.
• W2100785280 creator A5051030716 @default.
• W2100785280 creator A5068004396 @default.
• W2100785280 creator A5071542793 @default.
• W2100785280 creator A5079798885 @default.
• W2100785280 creator A5084596249 @default.
• W2100785280 creator A5087549185 @default.
• W2100785280 date "2008-01-14" @default.
• W2100785280 modified "2023-10-08" @default.
• W2100785280 title "Glucocorticoid Receptor Gene and Risk of Cardiovascular Disease" @default.
• W2100785280 cites W1950021792 @default.
• W2100785280 cites W2013976776 @default.
• W2100785280 cites W2019042602 @default.
• W2100785280 cites W2038779176 @default.
• W2100785280 cites W2044036686 @default.
• W2100785280 cites W2066963386 @default.
• W2100785280 cites W2074257679 @default.
• W2100785280 cites W2110755408 @default.
• W2100785280 cites W2113743444 @default.
• W2100785280 cites W2126309037 @default.
• W2100785280 cites W2133786107 @default.
• W2100785280 cites W2137432207 @default.
• W2100785280 cites W2139670574 @default.
• W2100785280 cites W2146773651 @default.
• W2100785280 cites W2147991645 @default.
• W2100785280 cites W2150691073 @default.
• W2100785280 cites W2156372290 @default.
• W2100785280 cites W2160776746 @default.
• W2100785280 cites W2162208431 @default.
• W2100785280 cites W2166705041 @default.
• W2100785280 cites W3080346889 @default.
• W2100785280 doi "https://doi.org/10.1001/archinternmed.2007.41" @default.
• W2100785280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18195193" @default.
• W2100785280 hasPublicationYear "2008" @default.
• W2100785280 type Work @default.
• W2100785280 sameAs 2100785280 @default.
• W2100785280 citedByCount "107" @default.
• W2100785280 countsByYear W21007852802012 @default.
• W2100785280 countsByYear W21007852802013 @default.
• W2100785280 countsByYear W21007852802014 @default.
• W2100785280 countsByYear W21007852802015 @default.
• W2100785280 countsByYear W21007852802016 @default.
• W2100785280 countsByYear W21007852802017 @default.
• W2100785280 countsByYear W21007852802018 @default.
• W2100785280 countsByYear W21007852802019 @default.
• W2100785280 countsByYear W21007852802020 @default.
• W2100785280 countsByYear W21007852802021 @default.
• W2100785280 countsByYear W21007852802022 @default.
• W2100785280 countsByYear W21007852802023 @default.
• W2100785280 crossrefType "journal-article" @default.
• W2100785280 hasAuthorship W2100785280A5004361068 @default.
• W2100785280 hasAuthorship W2100785280A5012841131 @default.
• W2100785280 hasAuthorship W2100785280A5031530236 @default.
• W2100785280 hasAuthorship W2100785280A5039611937 @default.
• W2100785280 hasAuthorship W2100785280A5046911852 @default.
• W2100785280 hasAuthorship W2100785280A5051030716 @default.
• W2100785280 hasAuthorship W2100785280A5068004396 @default.
• W2100785280 hasAuthorship W2100785280A5071542793 @default.
• W2100785280 hasAuthorship W2100785280A5079798885 @default.
• W2100785280 hasAuthorship W2100785280A5084596249 @default.
• W2100785280 hasAuthorship W2100785280A5087549185 @default.
• W2100785280 hasBestOaLocation W21007852801 @default.
• W2100785280 hasConcept C104317684 @default.
• W2100785280 hasConcept C126322002 @default.
• W2100785280 hasConcept C164705383 @default.
• W2100785280 hasConcept C180754005 @default.
• W2100785280 hasConcept C188816634 @default.
• W2100785280 hasConcept C197754878 @default.
• W2100785280 hasConcept C201903717 @default.
• W2100785280 hasConcept C207103383 @default.
• W2100785280 hasConcept C2779134260 @default.
• W2100785280 hasConcept C2780841215 @default.
• W2100785280 hasConcept C2908647359 @default.
• W2100785280 hasConcept C44249647 @default.
• W2100785280 hasConcept C500558357 @default.
• W2100785280 hasConcept C54355233 @default.
• W2100785280 hasConcept C59493245 @default.
• W2100785280 hasConcept C71924100 @default.
• W2100785280 hasConcept C86803240 @default.
• W2100785280 hasConcept C99454951 @default.
• W2100785280 hasConceptScore W2100785280C104317684 @default.
• W2100785280 hasConceptScore W2100785280C126322002 @default.
• W2100785280 hasConceptScore W2100785280C164705383 @default.
• W2100785280 hasConceptScore W2100785280C180754005 @default.
• W2100785280 hasConceptScore W2100785280C188816634 @default.
• W2100785280 hasConceptScore W2100785280C197754878 @default.
• W2100785280 hasConceptScore W2100785280C201903717 @default.
• W2100785280 hasConceptScore W2100785280C207103383 @default.
• W2100785280 hasConceptScore W2100785280C2779134260 @default.
• W2100785280 hasConceptScore W2100785280C2780841215 @default.
• W2100785280 hasConceptScore W2100785280C2908647359 @default.
• W2100785280 hasConceptScore W2100785280C44249647 @default.

• next