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• W2101112548 abstract "This paper proposes a simple and effective methodology for the scale-up and process transfer of freeze-drying recipes. Process modeling allows the study of the silico product evolution in a given freeze-dryer, and calculation of the operating conditions that result in the same product dynamics in different equipment. Few experiments are necessary to determine model parameters and to characterize the two freeze-dryers. The problem of the batch non-uniformity and the effect of the parameters' uncertainty are also addressed. The effectiveness of this approach is demonstrated by means of various examples." @default.
• W2101112548 created "2016-06-24" @default.
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• W2101112548 date "2011-11-01" @default.
• W2101112548 modified "2023-10-16" @default.
• W2101112548 title "Scale-up and Process Transfer of Freeze-Drying Recipes" @default.
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• W2101112548 doi "https://doi.org/10.1080/07373937.2011.597059" @default.
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