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• W2102903170 abstract "The role of Fas-mediated lysis of hepatocytes in hepatitis C virus (HCV)-induced injury is frequently discussed. We therefore analyzed the effect of the number of HCV antigen-expressing cells, the mode of antigen presentation, and the number of cytotoxic T lymphocytes in a coculture system mimicking cellular components of the liver. Here, we show that endogenously processed HCV proteins are capable of inducing bystander killing. We further demonstrate that 0.8 to 1.5% of cells presenting HCV antigens suffice to induce lysis of 10 to 29% of bystander cells, suggesting that the mechanism may be operative at low fractions of infected versus uninfected hepatocytes in vivo. Our data underscore the role of the Fas pathway in HCV-related liver injury and support the exploration of Fas-based treatment strategies for patients with chronic hepatitis C virus infection." @default.
• W2102903170 created "2016-06-24" @default.
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• W2102903170 date "2004-02-15" @default.
• W2102903170 modified "2023-09-27" @default.
• W2102903170 title "Cytotoxic T Lymphocytes Derived from Patients with Chronic Hepatitis C Virus Infection Kill Bystander Cells via Fas-FasL Interaction" @default.
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• W2102903170 doi "https://doi.org/10.1128/jvi.78.4.2152-2157.2004" @default.
• W2102903170 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/369426" @default.
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