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- W2103450058 abstract "Cross-beta amyloid is implicated in over 20 human diseases. Experiments suggest that specific sequence elements within amyloidogenic proteins play a major role in seeding amyloid formation. Identifying these seeding sequences is important for rationalizing the molecular mechanisms of amyloid formation and for elaborating therapeutic strategies that target amyloid. Theoretical techniques play an important role in facilitating the identification and structural characterization of putative seeding sequences; most amyloid species are not amenable to high resolution experimental structure techniques. In this study we have combined a coarse-grained physicochemical protein model with a highly efficient Monte Carlo sampling technique to identify amyloidogenic sequences in four proteins for which respective experimental peptide fragmentation data exist. Peptide sequences were defined as amyloidogenic if the ensemble structure predicted for three interacting peptides described a stable and regular three-stranded beta-sheet. For such peptides, free energies were calculated to provide a measure of amyloid propensity. The overall agreement between the experimental and predicted data is good, and we correctly identify several self-recognition motifs proposed to define the cross-beta amyloid fibril architectures of two of the proteins. Our results compare very favorably with those obtained using atomistic molecular dynamics methods, though our simulations are 30-40 times faster." @default.
- W2103450058 created "2016-06-24" @default.
- W2103450058 creator A5017704544 @default.
- W2103450058 creator A5082507688 @default.
- W2103450058 date "2009-03-01" @default.
- W2103450058 modified "2023-09-23" @default.
- W2103450058 title "Identification of amyloidogenic peptide sequences using a coarse-grained physicochemical model" @default.
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- W2103450058 doi "https://doi.org/10.1002/jcc.21085" @default.
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