FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2105531392> ?p ?o ?g. }

• W2105531392 endingPage "59" @default.
• W2105531392 startingPage "49" @default.
• W2105531392 abstract "Over the past two decades, much information has appeared on electrostatically driven molecular mechanisms of protein self-assembly and formation of aggregates of different morphology, varying from soluble amorphous structures to highly-ordered amyloid-like fibrils. Protein aggregation represents a special tool in biomedicine and biotechnology to produce biological materials for a wide range of applications. This has awakened interest in identification of pH-triggered regulators of transformation of aggregation-prone proteins into structures of higher order. The objective of the present study is to elucidate the effects of low-molecular-weight biogenic agents on aggregation and formation of supramolecular structures of human recombinant insulin, as a model therapeutic protein. Using dynamic light scattering, turbidimetry, circular dichroism, fluorescence spectroscopy, atomic force microscopy, transmission electron microscopy, and nuclear magnetic resonance, we have demonstrated that the amino acid l-arginine (Arg) has the striking potential to influence insulin aggregation propensity. It was shown that modification of the net charge of insulin induced by changes in the pH level of the incubation medium results in dramatic changes in the interaction of the protein with Arg. We have revealed the dual effects of Arg, highly dependent on the pH level of the solution – suppression or acceleration of the aggregation of insulin at pH 7.0 or 8.0, respectively. These effects can be regulated by manipulating the pH of the environment. The results of this study may be of interest for development of appropriate drug formulations and for the more general insight into the functioning of insulin in living systems, as the protein is known to release by exocytosis from pancreatic beta cells in a pH-dependent manner." @default.
• W2105531392 created "2016-06-24" @default.
• W2105531392 creator A5015569636 @default.
• W2105531392 creator A5034426690 @default.
• W2105531392 creator A5037083772 @default.
• W2105531392 creator A5039248761 @default.
• W2105531392 creator A5072715089 @default.
• W2105531392 creator A5089052737 @default.
• W2105531392 date "2015-02-01" @default.
• W2105531392 modified "2023-10-02" @default.
• W2105531392 title "pH-responsive modulation of insulin aggregation and structural transformation of the aggregates" @default.
• W2105531392 cites W1588296570 @default.
• W2105531392 cites W1972459558 @default.
• W2105531392 cites W1979409589 @default.
• W2105531392 cites W1981051419 @default.
• W2105531392 cites W1982709972 @default.
• W2105531392 cites W1986424517 @default.
• W2105531392 cites W1987845094 @default.
• W2105531392 cites W1987894698 @default.
• W2105531392 cites W1992985620 @default.
• W2105531392 cites W1995542474 @default.
• W2105531392 cites W1997512961 @default.
• W2105531392 cites W1997787046 @default.
• W2105531392 cites W2008289288 @default.
• W2105531392 cites W2011881868 @default.
• W2105531392 cites W2013857862 @default.
• W2105531392 cites W2015282297 @default.
• W2105531392 cites W2018761457 @default.
• W2105531392 cites W2019210215 @default.
• W2105531392 cites W2019590469 @default.
• W2105531392 cites W2030431187 @default.
• W2105531392 cites W2031093210 @default.
• W2105531392 cites W2041029973 @default.
• W2105531392 cites W2042230657 @default.
• W2105531392 cites W2043761562 @default.
• W2105531392 cites W2045267378 @default.
• W2105531392 cites W2045615711 @default.
• W2105531392 cites W2049125054 @default.
• W2105531392 cites W2085715883 @default.
• W2105531392 cites W2086760550 @default.
• W2105531392 cites W2090394300 @default.
• W2105531392 cites W2094746305 @default.
• W2105531392 cites W2144662157 @default.
• W2105531392 cites W2145563266 @default.
• W2105531392 cites W2316393185 @default.
• W2105531392 cites W2329122072 @default.
• W2105531392 cites W2330519951 @default.
• W2105531392 doi "https://doi.org/10.1016/j.biochi.2014.12.006" @default.
• W2105531392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25527324" @default.
• W2105531392 hasPublicationYear "2015" @default.
• W2105531392 type Work @default.
• W2105531392 sameAs 2105531392 @default.
• W2105531392 citedByCount "17" @default.
• W2105531392 countsByYear W21055313922016 @default.
• W2105531392 countsByYear W21055313922017 @default.
• W2105531392 countsByYear W21055313922018 @default.
• W2105531392 countsByYear W21055313922019 @default.
• W2105531392 countsByYear W21055313922021 @default.
• W2105531392 countsByYear W21055313922022 @default.
• W2105531392 countsByYear W21055313922023 @default.
• W2105531392 crossrefType "journal-article" @default.
• W2105531392 hasAuthorship W2105531392A5015569636 @default.
• W2105531392 hasAuthorship W2105531392A5034426690 @default.
• W2105531392 hasAuthorship W2105531392A5037083772 @default.
• W2105531392 hasAuthorship W2105531392A5039248761 @default.
• W2105531392 hasAuthorship W2105531392A5072715089 @default.
• W2105531392 hasAuthorship W2105531392A5089052737 @default.
• W2105531392 hasConcept C120665830 @default.
• W2105531392 hasConcept C121332964 @default.
• W2105531392 hasConcept C12554922 @default.
• W2105531392 hasConcept C131888329 @default.
• W2105531392 hasConcept C133571119 @default.
• W2105531392 hasConcept C134018914 @default.
• W2105531392 hasConcept C136238340 @default.
• W2105531392 hasConcept C14631669 @default.
• W2105531392 hasConcept C155672457 @default.
• W2105531392 hasConcept C171250308 @default.
• W2105531392 hasConcept C179104552 @default.
• W2105531392 hasConcept C185592680 @default.
• W2105531392 hasConcept C191486275 @default.
• W2105531392 hasConcept C192562407 @default.
• W2105531392 hasConcept C204328495 @default.
• W2105531392 hasConcept C2777633098 @default.
• W2105531392 hasConcept C2779306644 @default.
• W2105531392 hasConcept C47701112 @default.
• W2105531392 hasConcept C55493867 @default.
• W2105531392 hasConcept C86803240 @default.
• W2105531392 hasConceptScore W2105531392C120665830 @default.
• W2105531392 hasConceptScore W2105531392C121332964 @default.
• W2105531392 hasConceptScore W2105531392C12554922 @default.
• W2105531392 hasConceptScore W2105531392C131888329 @default.
• W2105531392 hasConceptScore W2105531392C133571119 @default.
• W2105531392 hasConceptScore W2105531392C134018914 @default.
• W2105531392 hasConceptScore W2105531392C136238340 @default.
• W2105531392 hasConceptScore W2105531392C14631669 @default.
• W2105531392 hasConceptScore W2105531392C155672457 @default.
• W2105531392 hasConceptScore W2105531392C171250308 @default.
• W2105531392 hasConceptScore W2105531392C179104552 @default.

• next