FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106710080> ?p ?o ?g. }

• W2106710080 endingPage "H1142" @default.
• W2106710080 startingPage "H1135" @default.
• W2106710080 abstract "Transient receptor potential vanilliod 1 (TRPV1) channels have recently been postulated to play a role in the vascular complications/consequences associated with diabetes despite the fact that the mechanisms through which TRPV1 regulates vascular function are not fully known. Accordingly, our goal was to define the mechanisms by which TRPV1 channels modulate vascular function and contribute to vascular dysfunction in diabetes. We subjected mice lacking TRPV1 [TRPV1 (−/−) ], db/ db, and control C57BLKS/J mice to in vivo infusion of the TRPV1 agonist capsaicin or the α-adrenergic agonist phenylephrine (PE) to examine the integrated circulatory actions of TRPV1. Capsaicin (1, 10, 20, and 100 μg/kg) dose dependently increased MAP in control mice (5.7 ± 1.6, 11.7 ± 2.1, 25.4 ± 3.4, and 51.6 ± 3.9%), which was attenuated in db/db mice (3.4 ± 2.1, 3.9 ± 2.1, 7.0 ± 3.3, and 17.9 ± 6.2%). TRPV1 (−/−) mice exhibited no changes in MAP in response to capsaicin, suggesting the actions of this agonist are specific to TRPV1 activation. Immunoblot analysis revealed decreased aortic TRPV1 protein expression in db/db compared with control mice. Capsaicin-induced responses were recorded following inhibition of endothelin A and B receptors (ET A /ET B ). Inhibition of ET A receptors abolished the capsaicin-mediated increases in MAP. Combined antagonism of ET A and ET B receptors did not further inhibit the capsaicin response. Cultured endothelial cell exposure to capsaicin increased endothelin production as shown by an endothelin ELISA assay, which was attenuated by inhibition of TRPV1 or endothelin-converting enzyme. TRPV1 channels contribute to the regulation of vascular reactivity and MAP via production of endothelin and subsequent activation of vascular ET A receptors. Impairment of TRPV1 channel function may contribute to vascular dysfunction in diabetes." @default.
• W2106710080 created "2016-06-24" @default.
• W2106710080 creator A5009593270 @default.
• W2106710080 creator A5021585479 @default.
• W2106710080 creator A5029503560 @default.
• W2106710080 creator A5039778000 @default.
• W2106710080 creator A5042007281 @default.
• W2106710080 creator A5044196607 @default.
• W2106710080 creator A5052210888 @default.
• W2106710080 creator A5063684581 @default.
• W2106710080 creator A5073596245 @default.
• W2106710080 date "2011-09-01" @default.
• W2106710080 modified "2023-10-17" @default.
• W2106710080 title "Endothelin-mediated in vivo pressor responses following TRPV1 activation" @default.
• W2106710080 cites W1488329806 @default.
• W2106710080 cites W1513266031 @default.
• W2106710080 cites W1516809639 @default.
• W2106710080 cites W1545907965 @default.
• W2106710080 cites W1593645241 @default.
• W2106710080 cites W1964375957 @default.
• W2106710080 cites W1968863191 @default.
• W2106710080 cites W1970330128 @default.
• W2106710080 cites W1996464360 @default.
• W2106710080 cites W1997357791 @default.
• W2106710080 cites W1997719147 @default.
• W2106710080 cites W2002199803 @default.
• W2106710080 cites W2018368856 @default.
• W2106710080 cites W2019562281 @default.
• W2106710080 cites W2022709209 @default.
• W2106710080 cites W2023320714 @default.
• W2106710080 cites W2023908228 @default.
• W2106710080 cites W2024342338 @default.
• W2106710080 cites W2030135937 @default.
• W2106710080 cites W2031218619 @default.
• W2106710080 cites W2042029726 @default.
• W2106710080 cites W2049845449 @default.
• W2106710080 cites W2051054397 @default.
• W2106710080 cites W2053596491 @default.
• W2106710080 cites W2054775780 @default.
• W2106710080 cites W2059369537 @default.
• W2106710080 cites W2061082589 @default.
• W2106710080 cites W2066503198 @default.
• W2106710080 cites W2077663629 @default.
• W2106710080 cites W2109293109 @default.
• W2106710080 cites W2110192403 @default.
• W2106710080 cites W2113768972 @default.
• W2106710080 cites W2119355019 @default.
• W2106710080 cites W2131939053 @default.
• W2106710080 cites W2144868091 @default.
• W2106710080 cites W2145491618 @default.
• W2106710080 cites W2151869895 @default.
• W2106710080 cites W2157294661 @default.
• W2106710080 cites W2160358510 @default.
• W2106710080 cites W2163363356 @default.
• W2106710080 cites W2164384569 @default.
• W2106710080 cites W2166046655 @default.
• W2106710080 cites W2167593450 @default.
• W2106710080 cites W2225782714 @default.
• W2106710080 cites W2316776522 @default.
• W2106710080 cites W2321033731 @default.
• W2106710080 cites W4248092016 @default.
• W2106710080 doi "https://doi.org/10.1152/ajpheart.00082.2011" @default.
• W2106710080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21705674" @default.
• W2106710080 hasPublicationYear "2011" @default.
• W2106710080 type Work @default.
• W2106710080 sameAs 2106710080 @default.
• W2106710080 citedByCount "18" @default.
• W2106710080 countsByYear W21067100802012 @default.
• W2106710080 countsByYear W21067100802013 @default.
• W2106710080 countsByYear W21067100802016 @default.
• W2106710080 countsByYear W21067100802017 @default.
• W2106710080 countsByYear W21067100802019 @default.
• W2106710080 countsByYear W21067100802020 @default.
• W2106710080 countsByYear W21067100802021 @default.
• W2106710080 countsByYear W21067100802022 @default.
• W2106710080 countsByYear W21067100802023 @default.
• W2106710080 crossrefType "journal-article" @default.
• W2106710080 hasAuthorship W2106710080A5009593270 @default.
• W2106710080 hasAuthorship W2106710080A5021585479 @default.
• W2106710080 hasAuthorship W2106710080A5029503560 @default.
• W2106710080 hasAuthorship W2106710080A5039778000 @default.
• W2106710080 hasAuthorship W2106710080A5042007281 @default.
• W2106710080 hasAuthorship W2106710080A5044196607 @default.
• W2106710080 hasAuthorship W2106710080A5052210888 @default.
• W2106710080 hasAuthorship W2106710080A5063684581 @default.
• W2106710080 hasAuthorship W2106710080A5073596245 @default.
• W2106710080 hasConcept C126322002 @default.
• W2106710080 hasConcept C134018914 @default.
• W2106710080 hasConcept C144980905 @default.
• W2106710080 hasConcept C149601957 @default.
• W2106710080 hasConcept C155164980 @default.
• W2106710080 hasConcept C160145004 @default.
• W2106710080 hasConcept C170493617 @default.
• W2106710080 hasConcept C185592680 @default.
• W2106710080 hasConcept C2777952589 @default.
• W2106710080 hasConcept C2778938600 @default.
• W2106710080 hasConcept C2780051329 @default.
• W2106710080 hasConcept C2780071552 @default.

• next