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• W2108017320 endingPage "4172" @default.
• W2108017320 startingPage "4163" @default.
• W2108017320 abstract "The present study examined whether the ability of mutant p53 to block apoptosis depended on its transcriptional activity. A core domain mutant p53 (143 Val to Ala), in which two N-terminal residues (22 and 23) essential for transactivation were also mutated (Leu to Glu and Trp to Ser, respectively), was examined. While p53 containing only the core mutation efficiently interfered with drug-induced apoptosis, further modification at the N-terminus abolished this blocking activity. Furthermore, expression of c-myc, a suggested target for core mutant p53 transactivation, was elevated in the core mutant p53-expressing cells, but was abolished in the presence of the transcription-deficient p53 core mutant. In addition, wild-type p53, mutated in the N-terminus (residues 22 and 23), was unable to induce apoptosis by itself. Nevertheless, it synergized with drugs in the induction of apoptosis. This suggests that the integrity of the N-terminus is essential for both the activity of wild-type p53 in apoptosis and for mutant p53-mediated block of drug-induced apoptosis. This supports the notion that core p53 mutants act via a gain of function mechanism." @default.
• W2108017320 created "2016-06-24" @default.
• W2108017320 creator A5002972268 @default.
• W2108017320 creator A5008169267 @default.
• W2108017320 creator A5013004159 @default.
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• W2108017320 creator A5072676965 @default.
• W2108017320 creator A5073746404 @default.
• W2108017320 creator A5091531697 @default.
• W2108017320 date "2001-08-01" @default.
• W2108017320 modified "2023-10-16" @default.
• W2108017320 title "Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis" @default.
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