FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108103623> ?p ?o ?g. }

• W2108103623 endingPage "35" @default.
• W2108103623 startingPage "2029" @default.
• W2108103623 abstract "The majority of alveolar rhabdomyosarcoma (ARMS) are distinguished through the paired box 3-forkhead box protein O1 (PAX3-FOXO1) fusion oncoprotein, being generated by a 2;13 chromosomal translocation. This fusion-positive ARMS is the most clinically difficult type of rhabdomyosarcoma. The present study characterized four genes [gremlin 1 (GREM1), death-associated protein kinase-1 (DAPK1), myogenic differentiation-1 (MYOD1), and hairy/enhancer-of-split related with YRPW motif-1 (HEY1)] as targets of PAX3-FOXO1.The expression of the four genes, PAX3-FOXO1, and v-myc myelocytomatosis viral-related oncogene, neuroblastoma-derived (avian) (MYCN) was determined in various ARMS cell models and primary tumors. The roles of PAX3-FOXO1 and MYCN expression were examined.Pulse-chase and cycloheximide experiments suggest that GREM1, DAPK1, and MYOD1 are directly regulated by PAX3-FOXO1. PAX3-FOXO1 appears to indirectly down-regulate HEY1 by up-regulating MYCN. Data reveal that the growth-suppressive activity of high PAX3-FOXO1 expression is closely-associated with up-regulation of the GREM1 and DAPK1 tumor-suppressor genes.This study characterized four downstream targets of PAX3-FOXO1 that contribute to the biological activities of growth suppression and myogenic differentiation." @default.
• W2108103623 created "2016-06-24" @default.
• W2108103623 creator A5074509270 @default.
• W2108103623 date "2013-05-01" @default.
• W2108103623 modified "2023-10-03" @default.
• W2108103623 title "Regulation of target genes of PAX3-FOXO1 in alveolar rhabdomyosarcoma." @default.
• W2108103623 cites W1530915757 @default.
• W2108103623 cites W1558871366 @default.
• W2108103623 cites W1910933204 @default.
• W2108103623 cites W1976427743 @default.
• W2108103623 cites W1978471017 @default.
• W2108103623 cites W1989752636 @default.
• W2108103623 cites W1989955809 @default.
• W2108103623 cites W1994302602 @default.
• W2108103623 cites W2001620055 @default.
• W2108103623 cites W2006872121 @default.
• W2108103623 cites W2023762717 @default.
• W2108103623 cites W2034389512 @default.
• W2108103623 cites W2037872087 @default.
• W2108103623 cites W2043406338 @default.
• W2108103623 cites W2047649751 @default.
• W2108103623 cites W2048172259 @default.
• W2108103623 cites W2049053107 @default.
• W2108103623 cites W2059381746 @default.
• W2108103623 cites W2060512760 @default.
• W2108103623 cites W2063951341 @default.
• W2108103623 cites W2064465439 @default.
• W2108103623 cites W2083833418 @default.
• W2108103623 cites W2089686996 @default.
• W2108103623 cites W2094061902 @default.
• W2108103623 cites W2094985383 @default.
• W2108103623 cites W2102352112 @default.
• W2108103623 cites W2102563614 @default.
• W2108103623 cites W2122129817 @default.
• W2108103623 cites W2124636729 @default.
• W2108103623 cites W2137480884 @default.
• W2108103623 cites W2157343834 @default.
• W2108103623 cites W2161178884 @default.
• W2108103623 cites W2171879013 @default.
• W2108103623 cites W2172107548 @default.
• W2108103623 cites W2175015884 @default.
• W2108103623 cites W2186784112 @default.
• W2108103623 cites W2317025328 @default.
• W2108103623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23645752" @default.
• W2108103623 hasPublicationYear "2013" @default.
• W2108103623 type Work @default.
• W2108103623 sameAs 2108103623 @default.
• W2108103623 citedByCount "4" @default.
• W2108103623 countsByYear W21081036232015 @default.
• W2108103623 countsByYear W21081036232017 @default.
• W2108103623 countsByYear W21081036232018 @default.
• W2108103623 countsByYear W21081036232023 @default.
• W2108103623 crossrefType "journal-article" @default.
• W2108103623 hasAuthorship W2108103623A5074509270 @default.
• W2108103623 hasConcept C104317684 @default.
• W2108103623 hasConcept C111829193 @default.
• W2108103623 hasConcept C123894998 @default.
• W2108103623 hasConcept C140149449 @default.
• W2108103623 hasConcept C142724271 @default.
• W2108103623 hasConcept C168609215 @default.
• W2108103623 hasConcept C2776522094 @default.
• W2108103623 hasConcept C2778256501 @default.
• W2108103623 hasConcept C2780844630 @default.
• W2108103623 hasConcept C2781018059 @default.
• W2108103623 hasConcept C29537977 @default.
• W2108103623 hasConcept C40767141 @default.
• W2108103623 hasConcept C502942594 @default.
• W2108103623 hasConcept C54355233 @default.
• W2108103623 hasConcept C71924100 @default.
• W2108103623 hasConcept C86339819 @default.
• W2108103623 hasConcept C86803240 @default.
• W2108103623 hasConceptScore W2108103623C104317684 @default.
• W2108103623 hasConceptScore W2108103623C111829193 @default.
• W2108103623 hasConceptScore W2108103623C123894998 @default.
• W2108103623 hasConceptScore W2108103623C140149449 @default.
• W2108103623 hasConceptScore W2108103623C142724271 @default.
• W2108103623 hasConceptScore W2108103623C168609215 @default.
• W2108103623 hasConceptScore W2108103623C2776522094 @default.
• W2108103623 hasConceptScore W2108103623C2778256501 @default.
• W2108103623 hasConceptScore W2108103623C2780844630 @default.
• W2108103623 hasConceptScore W2108103623C2781018059 @default.
• W2108103623 hasConceptScore W2108103623C29537977 @default.
• W2108103623 hasConceptScore W2108103623C40767141 @default.
• W2108103623 hasConceptScore W2108103623C502942594 @default.
• W2108103623 hasConceptScore W2108103623C54355233 @default.
• W2108103623 hasConceptScore W2108103623C71924100 @default.
• W2108103623 hasConceptScore W2108103623C86339819 @default.
• W2108103623 hasConceptScore W2108103623C86803240 @default.
• W2108103623 hasIssue "5" @default.
• W2108103623 hasLocation W21081036231 @default.
• W2108103623 hasOpenAccess W2108103623 @default.
• W2108103623 hasPrimaryLocation W21081036231 @default.
• W2108103623 hasRelatedWork W2048172259 @default.
• W2108103623 hasRelatedWork W2061622036 @default.
• W2108103623 hasRelatedWork W2095445212 @default.
• W2108103623 hasRelatedWork W2604497221 @default.
• W2108103623 hasRelatedWork W2791564799 @default.
• W2108103623 hasRelatedWork W2898277702 @default.

• next