Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108248889> ?p ?o ?g. }
- W2108248889 endingPage "4039" @default.
- W2108248889 startingPage "4030" @default.
- W2108248889 abstract "Helicobacter pylori infection is associated with altered gastric epithelial cell turnover. To evaluate the role of oxidative stress in cell death, gastric epithelial cells were exposed to various strains of H. pylori, inflammatory cytokines, and hydrogen peroxide in the absence or presence of antioxidant agents. Increased intracellular reactive oxygen species (ROS) were detected using a redox-sensitive fluorescent dye, a cytochrome c reduction assay, and measurements of glutathione. Apoptosis was evaluated by detecting DNA fragmentation and caspase activation. Infection with H. pylori or exposure of epithelial cells to hydrogen peroxide resulted in apoptosis and a dose-dependent increase in ROS generation that was enhanced by pretreatment with inflammatory cytokines. Basal levels of ROS were greater in epithelial cells isolated from gastric mucosal biopsy specimens from H. pylori-infected subjects than in cells from uninfected individuals. H. pylori strains bearing the cag pathogenicity island (PAI) induced higher levels of intracellular oxygen metabolites than isogenic cag PAI-deficient mutants. H. pylori infection and hydrogen peroxide exposure resulted in similar patterns of caspase 3 and 8 activation. Antioxidants inhibited both ROS generation and DNA fragmentation by H. pylori. These results indicate that bacterial factors and the host inflammatory response confer oxidative stress to the gastric epithelium during H. pylori infection that may lead to apoptosis." @default.
- W2108248889 created "2016-06-24" @default.
- W2108248889 creator A5002345698 @default.
- W2108248889 creator A5008196297 @default.
- W2108248889 creator A5012406527 @default.
- W2108248889 creator A5015655390 @default.
- W2108248889 creator A5030923798 @default.
- W2108248889 creator A5033108318 @default.
- W2108248889 creator A5052328316 @default.
- W2108248889 creator A5069268957 @default.
- W2108248889 creator A5073962501 @default.
- W2108248889 creator A5077467093 @default.
- W2108248889 date "2007-08-01" @default.
- W2108248889 modified "2023-10-01" @default.
- W2108248889 title "<i>Helicobacter pylori</i> Infection Induces Oxidative Stress and Programmed Cell Death in Human Gastric Epithelial Cells" @default.
- W2108248889 cites W1562359402 @default.
- W2108248889 cites W1574930510 @default.
- W2108248889 cites W1593624745 @default.
- W2108248889 cites W16288633 @default.
- W2108248889 cites W1633947760 @default.
- W2108248889 cites W1638074023 @default.
- W2108248889 cites W1657827244 @default.
- W2108248889 cites W182342000 @default.
- W2108248889 cites W1922753633 @default.
- W2108248889 cites W1962044813 @default.
- W2108248889 cites W1967782318 @default.
- W2108248889 cites W1971271340 @default.
- W2108248889 cites W1973232347 @default.
- W2108248889 cites W1979798333 @default.
- W2108248889 cites W1981883990 @default.
- W2108248889 cites W1993317326 @default.
- W2108248889 cites W1993910598 @default.
- W2108248889 cites W1997931429 @default.
- W2108248889 cites W2003647849 @default.
- W2108248889 cites W2004393474 @default.
- W2108248889 cites W2004691367 @default.
- W2108248889 cites W2009196421 @default.
- W2108248889 cites W2017772094 @default.
- W2108248889 cites W2018324596 @default.
- W2108248889 cites W2020138346 @default.
- W2108248889 cites W2021448147 @default.
- W2108248889 cites W2021758093 @default.
- W2108248889 cites W2022196541 @default.
- W2108248889 cites W2024650397 @default.
- W2108248889 cites W20323162 @default.
- W2108248889 cites W2035703380 @default.
- W2108248889 cites W2036179712 @default.
- W2108248889 cites W2053161326 @default.
- W2108248889 cites W2057587996 @default.
- W2108248889 cites W2062145914 @default.
- W2108248889 cites W2064924915 @default.
- W2108248889 cites W2064949754 @default.
- W2108248889 cites W2071129528 @default.
- W2108248889 cites W2073888106 @default.
- W2108248889 cites W2075917081 @default.
- W2108248889 cites W2083316920 @default.
- W2108248889 cites W2093606430 @default.
- W2108248889 cites W2096609115 @default.
- W2108248889 cites W2097984152 @default.
- W2108248889 cites W2102261966 @default.
- W2108248889 cites W2104807853 @default.
- W2108248889 cites W2106835946 @default.
- W2108248889 cites W2108467352 @default.
- W2108248889 cites W2110132014 @default.
- W2108248889 cites W2112256200 @default.
- W2108248889 cites W2113363693 @default.
- W2108248889 cites W2117355475 @default.
- W2108248889 cites W2117875205 @default.
- W2108248889 cites W2117981959 @default.
- W2108248889 cites W2118842297 @default.
- W2108248889 cites W2119166971 @default.
- W2108248889 cites W2128172186 @default.
- W2108248889 cites W2130644701 @default.
- W2108248889 cites W2133452916 @default.
- W2108248889 cites W2142113094 @default.
- W2108248889 cites W2142687085 @default.
- W2108248889 cites W2143266772 @default.
- W2108248889 cites W2151826056 @default.
- W2108248889 cites W2152260988 @default.
- W2108248889 cites W2153419053 @default.
- W2108248889 cites W2156494845 @default.
- W2108248889 cites W2159747058 @default.
- W2108248889 cites W2161990266 @default.
- W2108248889 cites W2171475728 @default.
- W2108248889 cites W2171953345 @default.
- W2108248889 cites W2184359604 @default.
- W2108248889 cites W2188751783 @default.
- W2108248889 cites W2192224625 @default.
- W2108248889 cites W2192332048 @default.
- W2108248889 cites W2245830732 @default.
- W2108248889 cites W2258939519 @default.
- W2108248889 cites W2320244329 @default.
- W2108248889 cites W2329680201 @default.
- W2108248889 cites W2336853834 @default.
- W2108248889 cites W4237961346 @default.
- W2108248889 cites W71916623 @default.
- W2108248889 doi "https://doi.org/10.1128/iai.00172-07" @default.
- W2108248889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1952011" @default.