FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2108451330> ?p ?o ?g. }

• W2108451330 endingPage "2485" @default.
• W2108451330 startingPage "2475" @default.
• W2108451330 abstract "The pluripotential cell-specific gene Nanog encodes a homeodomain-bearing transcription factor required for maintaining the undifferentiated state of stem cells. However, the molecular mechanisms that regulate Nanog gene expression are largely unknown. To address this important issue, we used luciferase assays to monitor the relative activities of deletion fragments from the 5'-flanking region of the gene. An adjacent pair of highly conserved Octamer- and Sox-binding sites was found to be essential for activating pluripotential state-specific gene expression. Furthermore, the 5'-end fragment encompassing the Octamer/Sox element was sufficient for inducing the proper expression of a green fluorescent protein reporter gene even in human embryonic stem (ES) cells. The potential of OCT4 and SOX2 to bind to this element was verified by electrophoretic mobility shift assays with extracts from F9 embryonal carcinoma cells and embryonic germ cells derived from embryonic day 12.5 embryos. However, in ES cell extracts, a complex of OCT4 with an undefined factor preferentially bound to the Octamer/Sox element. Thus, Nanog transcription may be regulated through an interaction between Oct4 and Sox2 or a novel pluripotential cell-specific Sox element-binding factor which is prominent in ES cells." @default.
• W2108451330 created "2016-06-24" @default.
• W2108451330 creator A5010867955 @default.
• W2108451330 creator A5016703254 @default.
• W2108451330 creator A5030073990 @default.
• W2108451330 creator A5034740783 @default.
• W2108451330 creator A5034769415 @default.
• W2108451330 creator A5036140294 @default.
• W2108451330 creator A5036958795 @default.
• W2108451330 creator A5084693578 @default.
• W2108451330 date "2005-03-01" @default.
• W2108451330 modified "2023-10-12" @default.
• W2108451330 title "Octamer and Sox Elements Are Required for Transcriptional <i>cis</i> Regulation of <i>Nanog</i> Gene Expression" @default.
• W2108451330 cites W1608762409 @default.
• W2108451330 cites W1665744978 @default.
• W2108451330 cites W1923085229 @default.
• W2108451330 cites W1951882906 @default.
• W2108451330 cites W1957763880 @default.
• W2108451330 cites W1975163937 @default.
• W2108451330 cites W1981088384 @default.
• W2108451330 cites W1981253959 @default.
• W2108451330 cites W1989429936 @default.
• W2108451330 cites W1992160731 @default.
• W2108451330 cites W1992949513 @default.
• W2108451330 cites W1995559307 @default.
• W2108451330 cites W2011077415 @default.
• W2108451330 cites W2015469705 @default.
• W2108451330 cites W2018855387 @default.
• W2108451330 cites W2023745283 @default.
• W2108451330 cites W2035134361 @default.
• W2108451330 cites W2038548460 @default.
• W2108451330 cites W2043627182 @default.
• W2108451330 cites W2050535237 @default.
• W2108451330 cites W2055196229 @default.
• W2108451330 cites W2064358462 @default.
• W2108451330 cites W2066364577 @default.
• W2108451330 cites W2071241326 @default.
• W2108451330 cites W2075087486 @default.
• W2108451330 cites W2078560549 @default.
• W2108451330 cites W2086943348 @default.
• W2108451330 cites W2097326193 @default.
• W2108451330 cites W2107141327 @default.
• W2108451330 cites W2118290853 @default.
• W2108451330 cites W2122441400 @default.
• W2108451330 cites W2123986423 @default.
• W2108451330 cites W2126851387 @default.
• W2108451330 cites W2150163104 @default.
• W2108451330 cites W2162259106 @default.
• W2108451330 cites W2162504561 @default.
• W2108451330 cites W2165135585 @default.
• W2108451330 cites W2166670696 @default.
• W2108451330 cites W2167234515 @default.
• W2108451330 cites W2167250543 @default.
• W2108451330 cites W2169529166 @default.
• W2108451330 cites W2292788090 @default.
• W2108451330 doi "https://doi.org/10.1128/mcb.25.6.2475-2485.2005" @default.
• W2108451330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1061601" @default.
• W2108451330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15743839" @default.
• W2108451330 hasPublicationYear "2005" @default.
• W2108451330 type Work @default.
• W2108451330 sameAs 2108451330 @default.
• W2108451330 citedByCount "464" @default.
• W2108451330 countsByYear W21084513302012 @default.
• W2108451330 countsByYear W21084513302013 @default.
• W2108451330 countsByYear W21084513302014 @default.
• W2108451330 countsByYear W21084513302015 @default.
• W2108451330 countsByYear W21084513302016 @default.
• W2108451330 countsByYear W21084513302017 @default.
• W2108451330 countsByYear W21084513302018 @default.
• W2108451330 countsByYear W21084513302019 @default.
• W2108451330 countsByYear W21084513302020 @default.
• W2108451330 countsByYear W21084513302021 @default.
• W2108451330 countsByYear W21084513302022 @default.
• W2108451330 countsByYear W21084513302023 @default.
• W2108451330 crossrefType "journal-article" @default.
• W2108451330 hasAuthorship W2108451330A5010867955 @default.
• W2108451330 hasAuthorship W2108451330A5016703254 @default.
• W2108451330 hasAuthorship W2108451330A5030073990 @default.
• W2108451330 hasAuthorship W2108451330A5034740783 @default.
• W2108451330 hasAuthorship W2108451330A5034769415 @default.
• W2108451330 hasAuthorship W2108451330A5036140294 @default.
• W2108451330 hasAuthorship W2108451330A5036958795 @default.
• W2108451330 hasAuthorship W2108451330A5084693578 @default.
• W2108451330 hasBestOaLocation W21084513301 @default.
• W2108451330 hasConcept C104317684 @default.
• W2108451330 hasConcept C107459253 @default.
• W2108451330 hasConcept C121587040 @default.
• W2108451330 hasConcept C145103041 @default.
• W2108451330 hasConcept C150194340 @default.
• W2108451330 hasConcept C153911025 @default.
• W2108451330 hasConcept C161733203 @default.
• W2108451330 hasConcept C165864922 @default.
• W2108451330 hasConcept C173681060 @default.
• W2108451330 hasConcept C183978625 @default.
• W2108451330 hasConcept C196287685 @default.
• W2108451330 hasConcept C207701140 @default.
• W2108451330 hasConcept C2777933648 @default.
• W2108451330 hasConcept C54355233 @default.

• next