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- W2108489321 abstract "A new series of substituted benzylamino- and heterocyclylmethylamino carbodithioate derivatives of 4-(3H)-quinazolinone were synthesized via four steps starting from 2-amino-5-methylbenzoic acid and initially screened against A-549 (human non-small cell lung cancer), HCT-8 (human colon cancer), and Bel-7402 (human liver cancer) cell lines at the single concentration of 5 μg/mL using the colorimetric MTT assay. The IC50 values were determined for the compounds reaching ⪈70% inhibition in primary screening by serial dilution. Among the newly synthesized compounds, 9n exhibited potent in vitro cytotoxicity against A-549, HCT-8, and Bel-7402 cell lines with the IC50 values of 1.65, 0.93, and 1.43 μM, respectively." @default.
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- W2108489321 date "2006-05-01" @default.
- W2108489321 modified "2023-10-07" @default.
- W2108489321 title "Synthesis of Substituted Benzylamino- and Heterocyclylmethylamino Carbodithioate Derivatives of 4-(3H)-Quinazolinone and their Cytotoxic Activity" @default.
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- W2108489321 doi "https://doi.org/10.1002/ardp.200500264" @default.
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