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• W2110360181 abstract "A HeLa cell transient-expression assay system was used to determine if isolated immediate early (alpha) genes from herpes simplex virus (HSV) could transcriptionally activate (transactivate) the type 1 (HSV-1) thymidine kinase (TK) gene [an early (beta) gene]. Cells transfected with the TK gene alone transcribed very low levels of TK RNA. Cells cotransfected with plasmids bearing the sequences that encode the alpha-gene product infected cell protein 0 or 4 (ICP0 or ICP4) and the TK gene faithfully transcribed high levels of TK RNA. The plasmid containing the sequences encoding ICP0 was a more potent transactivator than the plasmid containing the sequences for ICP4." @default.
• W2110360181 created "2016-06-24" @default.
• W2110360181 creator A5048640524 @default.
• W2110360181 creator A5074507585 @default.
• W2110360181 date "1985-08-01" @default.
• W2110360181 modified "2023-10-17" @default.
• W2110360181 title "Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene." @default.
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• W2110360181 doi "https://doi.org/10.1073/pnas.82.16.5265" @default.
• W2110360181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/390548" @default.
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