FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110365214> ?p ?o ?g. }

• W2110365214 endingPage "1584" @default.
• W2110365214 startingPage "1579" @default.
• W2110365214 abstract "<b>Background:</b> Osteoporosis is an important cause of morbidity in patients with Crohn’s disease. The pathogenesis of reduced bone mineral density (BMD) is multifactorial. A range of genetic factors have been implicated in other populations of patients with osteoporosis. <b>Aim:</b> To investigate the influence of interleukin 6 (<i>IL-6</i>), collagen type 1α1 (<i>COL1A1</i>), and vitamin D receptor gene (<i>VDR</i>) single nucleotide polymorphisms (SNP) on BMD in patients with Crohn’s disease. <b>Patients:</b> A cohort of 245 well characterised patients with Crohn’s disease were recruited from the inflammatory bowel disease register at the Freeman Hospital and Royal Victoria Infirmary, Newcastle upon Tyne, and the Queen Elizabeth Hospital, Gateshead, UK. <b>Methods:</b> Patients were genotyped for <i>IL-6</i> C-174G SNP, <i>COL1A1</i> Sp1 binding site G T SNP, <i>VDR Taq1</i>, and <i>Fok1</i> SNPs, and <i>CARD15</i> R702W, G908R, and L1007fs SNPs. BMD was measured at the lumbar spine (LSP) and hip using dual energy <i>x</i> ray absorptiometry. <b>Results:</b> A total of 158 female and 87 male patients, aged 24–70 years (mean 44), were recruited. There were no significant differences in the distribution of the tested SNPs when analysed for age, body mass index, pre/post-menopausal status, smoking, or steroid use. Two hundred and thirteen patients were genotyped for the <i>IL-6</i> SNP. LSP and total hip BMD was significantly lower in patients with the GG genotype (48%) than the CC genotype (15%) (p = 0.041, p = 0.014). One hundred and eighty patients were genotyped for the <i>COL1A1</i> SNP. There was no significant difference in BMD at LSP. Hip BMD was significantly lower in heterozygous patients compared with homozygous wild-types (p = 0.034). There were no significant differences in BMD between genotypes for the two <i>VDR</i> SNPs or the <i>CARD15</i> genotypes examined. <b>Conclusion:</b><i>IL-6</i> and <i>COL1A1</i> gene polymorphisms influence BMD in patients with Crohn’s disease but the particular <i>VDR</i> gene polymorphisms studied do not have a major effect." @default.
• W2110365214 created "2016-06-24" @default.
• W2110365214 creator A5000280177 @default.
• W2110365214 creator A5009017786 @default.
• W2110365214 creator A5036281306 @default.
• W2110365214 creator A5042932407 @default.
• W2110365214 creator A5053608580 @default.
• W2110365214 creator A5079101398 @default.
• W2110365214 creator A5084283624 @default.
• W2110365214 creator A5084621597 @default.
• W2110365214 date "2005-11-01" @default.
• W2110365214 modified "2023-10-14" @default.
• W2110365214 title "Influence of IL-6, COL1A1, and VDR gene polymorphisms on bone mineral density in Crohn's disease" @default.
• W2110365214 cites W1525779636 @default.
• W2110365214 cites W1547160425 @default.
• W2110365214 cites W1642457845 @default.
• W2110365214 cites W1966411863 @default.
• W2110365214 cites W1969767037 @default.
• W2110365214 cites W1973591042 @default.
• W2110365214 cites W1976640699 @default.
• W2110365214 cites W1979769181 @default.
• W2110365214 cites W1996707061 @default.
• W2110365214 cites W1998501465 @default.
• W2110365214 cites W1998818726 @default.
• W2110365214 cites W2000786522 @default.
• W2110365214 cites W2006849448 @default.
• W2110365214 cites W2016666406 @default.
• W2110365214 cites W2035559267 @default.
• W2110365214 cites W2036125852 @default.
• W2110365214 cites W2036360679 @default.
• W2110365214 cites W2044908713 @default.
• W2110365214 cites W2057982124 @default.
• W2110365214 cites W2059991164 @default.
• W2110365214 cites W2064699495 @default.
• W2110365214 cites W2072527511 @default.
• W2110365214 cites W2074790732 @default.
• W2110365214 cites W2076440836 @default.
• W2110365214 cites W2077804411 @default.
• W2110365214 cites W2080783947 @default.
• W2110365214 cites W2084732574 @default.
• W2110365214 cites W2089022749 @default.
• W2110365214 cites W2091134382 @default.
• W2110365214 cites W2094554465 @default.
• W2110365214 cites W2095218977 @default.
• W2110365214 cites W2099451618 @default.
• W2110365214 cites W2101887443 @default.
• W2110365214 cites W2107789045 @default.
• W2110365214 cites W2108872477 @default.
• W2110365214 cites W2116847662 @default.
• W2110365214 cites W2121444149 @default.
• W2110365214 cites W2122235259 @default.
• W2110365214 cites W2122486133 @default.
• W2110365214 cites W2133627139 @default.
• W2110365214 cites W2141468077 @default.
• W2110365214 cites W2160398741 @default.
• W2110365214 cites W2321505964 @default.
• W2110365214 cites W2335475908 @default.
• W2110365214 cites W40842589 @default.
• W2110365214 doi "https://doi.org/10.1136/gut.2005.064212" @default.
• W2110365214 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1774753" @default.
• W2110365214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16009674" @default.
• W2110365214 hasPublicationYear "2005" @default.
• W2110365214 type Work @default.
• W2110365214 sameAs 2110365214 @default.
• W2110365214 citedByCount "36" @default.
• W2110365214 countsByYear W21103652142012 @default.
• W2110365214 countsByYear W21103652142013 @default.
• W2110365214 countsByYear W21103652142014 @default.
• W2110365214 countsByYear W21103652142015 @default.
• W2110365214 countsByYear W21103652142016 @default.
• W2110365214 countsByYear W21103652142017 @default.
• W2110365214 countsByYear W21103652142019 @default.
• W2110365214 countsByYear W21103652142020 @default.
• W2110365214 countsByYear W21103652142022 @default.
• W2110365214 crossrefType "journal-article" @default.
• W2110365214 hasAuthorship W2110365214A5000280177 @default.
• W2110365214 hasAuthorship W2110365214A5009017786 @default.
• W2110365214 hasAuthorship W2110365214A5036281306 @default.
• W2110365214 hasAuthorship W2110365214A5042932407 @default.
• W2110365214 hasAuthorship W2110365214A5053608580 @default.
• W2110365214 hasAuthorship W2110365214A5079101398 @default.
• W2110365214 hasAuthorship W2110365214A5084283624 @default.
• W2110365214 hasAuthorship W2110365214A5084621597 @default.
• W2110365214 hasBestOaLocation W21103652141 @default.
• W2110365214 hasConcept C104317684 @default.
• W2110365214 hasConcept C124490489 @default.
• W2110365214 hasConcept C126322002 @default.
• W2110365214 hasConcept C135763542 @default.
• W2110365214 hasConcept C139275648 @default.
• W2110365214 hasConcept C153209595 @default.
• W2110365214 hasConcept C179639408 @default.
• W2110365214 hasConcept C2775854910 @default.
• W2110365214 hasConcept C2776541429 @default.
• W2110365214 hasConcept C2776886416 @default.
• W2110365214 hasConcept C2778260677 @default.
• W2110365214 hasConcept C2779134260 @default.
• W2110365214 hasConcept C2779280984 @default.
• W2110365214 hasConcept C2779329777 @default.

• next