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• W2110368878 endingPage "2609" @default.
• W2110368878 startingPage "2599" @default.
• W2110368878 abstract "Borrelia burgdorferi regulates gene expression in response to environmental conditions, including temperature, pH, redox potential and host factors. B. burgdorferi encodes a PerR homologue designated BosR, which presumably serves as a global regulator of genes involved in the oxidative stress response. Infectious B. burgdorferi strain B31 is resistant to oxidative stressors in vitro , whereas the non-infectious isolate was sensitive due, in part, to a point mutation that converts an arginine to a lysine at residue 39 of BosR. Subsequent insertional inactivation of this bosRR39K allele ( bosRR39K : : kan R ) restored resistance to oxidative stressors. These observations suggest that the B. burgdorferi non-infectious bosRR39K : : kan R strain may transcribe genes that are also expressed in infectious B. burgdorferi cells, but are repressed in the bosRR39K background, thus explaining the different oxidative stress phenotypes observed between these isolates. To test this hypothesis, macroarray technology and quantitative RT-PCR were utilized to compare the transcriptional profiles from the isogenic bosRR39K and bosRR39K : : kan R isolates. Array data indicated that 88 ORFs were significantly expressed in the absence of BosRR39K. Since most affected genes mapped to the chromosome, it is likely that these genes define an important physiologic response for B. burgdorferi . Included within the genes identified was the detoxification gene sodA , as well as other loci not overtly linked to oxidative stress. These results suggest that a putative BosR regulon, as defined by the bosRR39K allele, is required to combat toxic oxidative intermediates, but may also be involved in adaptive strategies that are independent of reactive oxygen species." @default.
• W2110368878 created "2016-06-24" @default.
• W2110368878 creator A5037183809 @default.
• W2110368878 creator A5055915670 @default.
• W2110368878 creator A5067154316 @default.
• W2110368878 date "2006-09-01" @default.
• W2110368878 modified "2023-09-25" @default.
• W2110368878 title "Transcriptional profiling of Borrelia burgdorferi containing a unique bosR allele identifies a putative oxidative stress regulon" @default.
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• W2110368878 doi "https://doi.org/10.1099/mic.0.28996-0" @default.
• W2110368878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16946255" @default.
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