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• W2111524961 startingPage "e74939" @default.
• W2111524961 abstract "Oxidative stress is a well-known biological process that occurs in all respiring cells and is involved in pathophysiological processes such as aging and apoptosis. Oxidative stress agents include peroxides such as hydrogen peroxide, cumene hydroperoxide, and linoleic acid hydroperoxide, the thiol oxidant diamide, and menadione, a generator of superoxide, amongst others. The present study analyzed the early temporal genome-wide transcriptional response of Saccharomyces cerevisiae to oxidative stress induced by the aromatic peroxide cumene hydroperoxide. The accurate dataset obtained, supported by the use of temporal controls, biological replicates and well controlled growth conditions, provided a detailed picture of the early dynamics of the process. We identified a set of genes previously not implicated in the oxidative stress response, including several transcriptional regulators showing a fast transient response, suggesting a coordinated process in the transcriptional reprogramming. We discuss the role of the glutathione, thioredoxin and reactive oxygen species-removing systems, the proteasome and the pentose phosphate pathway. A data-driven clustering of the expression patterns identified one specific cluster that mostly consisted of genes known to be regulated by the Yap1p and Skn7p transcription factors, emphasizing their mediator role in the transcriptional response to oxidants. Comparison of our results with data reported for hydrogen peroxide identified 664 genes that specifically respond to cumene hydroperoxide, suggesting distinct transcriptional responses to these two peroxides. Genes up-regulated only by cumene hydroperoxide are mainly related to the cell membrane and cell wall, and proteolysis process, while those down-regulated only by this aromatic peroxide are involved in mitochondrial function." @default.
• W2111524961 created "2016-06-24" @default.
• W2111524961 creator A5001597182 @default.
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• W2111524961 creator A5042984164 @default.
• W2111524961 creator A5075088916 @default.
• W2111524961 creator A5091010756 @default.
• W2111524961 date "2013-09-20" @default.
• W2111524961 modified "2023-09-25" @default.
• W2111524961 title "The Genome-Wide Early Temporal Response of Saccharomyces cerevisiae to Oxidative Stress Induced by Cumene Hydroperoxide" @default.
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• W2111524961 doi "https://doi.org/10.1371/journal.pone.0074939" @default.
• W2111524961 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3779239" @default.
• W2111524961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24073228" @default.
• W2111524961 hasPublicationYear "2013" @default.
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