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• W2113990938 abstract "Abstract Background We evaluated the effects of a levosimendan ( LS )‐based strategy compared with standard inotropic therapy on renal function in heart transplantation. Methods and results Using a randomized study design, 94 patients were assigned to LS‐based therapy or standard inotropic support. At the time of transplantation, the groups did not differ in age, gender, heart failure etiology, hemodynamic profile, LVEF, or comorbidities. While there were no differences in serum creatinine ( sC r) or eGFR between groups at baseline, patients in the LS group had a greater increase in their relative eGFR (62% vs. 12%, p = 0.002) and a lower incidence of acute kidney injury (AKI) (28% vs. 6%, p = 0.01) during the first post‐transplant week. On logistic regression analysis, correlates of AKI were randomization to LS therapy (OR = 0.21 [0.09–0.62], p = 0.01), baseline renal dysfunction (OR = 3.9 [1.1–13.6], p = 0.032), and diabetes mellitus (OR = 4.2 [1.1–16.5], p = 0.038). However, LS was associated with a greater need for additional norepinephrine therapy (40 [85%] vs. 15 [31%], p < 0.001) and a trend toward longer intensive care unit stay (9.5 ± 9.0 d vs. 7.0 ± 6.0 d, p = 0.13). Conclusions In patients undergoing heart transplantation, levosimendan‐based strategy may be associated with better renal function when compared to standard therapy." @default.
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• W2113990938 date "2014-08-14" @default.
• W2113990938 modified "2023-10-18" @default.
• W2113990938 title "The effects of levosimendan on renal function early after heart transplantation: results from a pilot randomized trial" @default.
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• W2113990938 doi "https://doi.org/10.1111/ctr.12424" @default.
• W2113990938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25053182" @default.
• W2113990938 hasPublicationYear "2014" @default.
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