FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116098355> ?p ?o ?g. }

• W2116098355 endingPage "368" @default.
• W2116098355 startingPage "362" @default.
• W2116098355 abstract "We have studied amphotericin B concentrations in tissues of 13 cancer patients who died after having received 75 to 1,110 mg (total dose) of amphotericin B-deoxycholate for suspected or proven disseminated fungal infection. Amphotericin B concentrations were measured by high-pressure liquid chromatography (HPLC) and by bioassay, the latter being done on tissue homogenates as well as on tissue methanolic extracts. The fungistatic and fungicidal titers of the tissue homogenates were also tested against three strains of Candida albicans and one strain of Aspergillus fumigatus. Tissue concentrations of amphotericin B measured by HPLC varied with the tested tissues as well as with the total dose of amphotericin B-deoxycholate administered and ranged from 0.4 to 147.1 micrograms/g. A mean of 38.3% (range, 23.0 to 51.3%) of the total dose was recovered by HPLC from all of the tested organs. Bioassay of tissue methanolic extracts reached 58 to 81% of the concentration measured by HPLC, whereas only 15 to 41% was recovered from the homogenates. Overall, 27.5% of the total dose was recovered from the liver, 5.2% was recovered from the spleen, 3.2% was recovered from the lungs, and 1.5% was recovered from the kidneys. The median concentration in bile was 7.3 micrograms/ml, suggesting that biliary excretion could contribute to amphotericin B elimination to an estimated range of 0.8 to 14.6% of the daily dose. Fungicidal titers were seldom measured in tissues, but fungistatic titers were observed and were linearly correlated with amphotericin B concentration measured by HPLC. In conclusion, only a small proportion of the amphotericin B administered as amphotericin B-deoxycholate to patients seems diffusible and bioactive." @default.
• W2116098355 created "2016-06-24" @default.
• W2116098355 creator A5035310203 @default.
• W2116098355 creator A5057752177 @default.
• W2116098355 creator A5074291056 @default.
• W2116098355 creator A5075200156 @default.
• W2116098355 creator A5091573069 @default.
• W2116098355 date "1989-03-01" @default.
• W2116098355 modified "2023-10-05" @default.
• W2116098355 title "Tissue concentrations and bioactivity of amphotericin B in cancer patients treated with amphotericin B-deoxycholate" @default.
• W2116098355 cites W1534546565 @default.
• W2116098355 cites W1971391507 @default.
• W2116098355 cites W1994731230 @default.
• W2116098355 cites W2001402251 @default.
• W2116098355 cites W2004832477 @default.
• W2116098355 cites W2030371182 @default.
• W2116098355 cites W2035302724 @default.
• W2116098355 cites W2053821655 @default.
• W2116098355 cites W2082087628 @default.
• W2116098355 cites W2082996726 @default.
• W2116098355 cites W2083356192 @default.
• W2116098355 cites W2084068955 @default.
• W2116098355 cites W2120541149 @default.
• W2116098355 cites W2140450407 @default.
• W2116098355 cites W2156730883 @default.
• W2116098355 cites W2270944920 @default.
• W2116098355 doi "https://doi.org/10.1128/aac.33.3.362" @default.
• W2116098355 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/171494" @default.
• W2116098355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2658785" @default.
• W2116098355 hasPublicationYear "1989" @default.
• W2116098355 type Work @default.
• W2116098355 sameAs 2116098355 @default.
• W2116098355 citedByCount "97" @default.
• W2116098355 countsByYear W21160983552012 @default.
• W2116098355 countsByYear W21160983552013 @default.
• W2116098355 countsByYear W21160983552014 @default.
• W2116098355 countsByYear W21160983552016 @default.
• W2116098355 countsByYear W21160983552017 @default.
• W2116098355 countsByYear W21160983552018 @default.
• W2116098355 countsByYear W21160983552019 @default.
• W2116098355 countsByYear W21160983552020 @default.
• W2116098355 countsByYear W21160983552021 @default.
• W2116098355 countsByYear W21160983552022 @default.
• W2116098355 countsByYear W21160983552023 @default.
• W2116098355 crossrefType "journal-article" @default.
• W2116098355 hasAuthorship W2116098355A5035310203 @default.
• W2116098355 hasAuthorship W2116098355A5057752177 @default.
• W2116098355 hasAuthorship W2116098355A5074291056 @default.
• W2116098355 hasAuthorship W2116098355A5075200156 @default.
• W2116098355 hasAuthorship W2116098355A5091573069 @default.
• W2116098355 hasBestOaLocation W21160983551 @default.
• W2116098355 hasConcept C104488531 @default.
• W2116098355 hasConcept C112705442 @default.
• W2116098355 hasConcept C179998833 @default.
• W2116098355 hasConcept C185592680 @default.
• W2116098355 hasConcept C2779548794 @default.
• W2116098355 hasConcept C2779629538 @default.
• W2116098355 hasConcept C2780402444 @default.
• W2116098355 hasConcept C2780917455 @default.
• W2116098355 hasConcept C2909039274 @default.
• W2116098355 hasConcept C43617362 @default.
• W2116098355 hasConcept C54355233 @default.
• W2116098355 hasConcept C86803240 @default.
• W2116098355 hasConcept C89423630 @default.
• W2116098355 hasConcept C98274493 @default.
• W2116098355 hasConceptScore W2116098355C104488531 @default.
• W2116098355 hasConceptScore W2116098355C112705442 @default.
• W2116098355 hasConceptScore W2116098355C179998833 @default.
• W2116098355 hasConceptScore W2116098355C185592680 @default.
• W2116098355 hasConceptScore W2116098355C2779548794 @default.
• W2116098355 hasConceptScore W2116098355C2779629538 @default.
• W2116098355 hasConceptScore W2116098355C2780402444 @default.
• W2116098355 hasConceptScore W2116098355C2780917455 @default.
• W2116098355 hasConceptScore W2116098355C2909039274 @default.
• W2116098355 hasConceptScore W2116098355C43617362 @default.
• W2116098355 hasConceptScore W2116098355C54355233 @default.
• W2116098355 hasConceptScore W2116098355C86803240 @default.
• W2116098355 hasConceptScore W2116098355C89423630 @default.
• W2116098355 hasConceptScore W2116098355C98274493 @default.
• W2116098355 hasIssue "3" @default.
• W2116098355 hasLocation W21160983551 @default.
• W2116098355 hasLocation W21160983552 @default.
• W2116098355 hasLocation W21160983553 @default.
• W2116098355 hasOpenAccess W2116098355 @default.
• W2116098355 hasPrimaryLocation W21160983551 @default.
• W2116098355 hasRelatedWork W2060425192 @default.
• W2116098355 hasRelatedWork W2063287049 @default.
• W2116098355 hasRelatedWork W2129423527 @default.
• W2116098355 hasRelatedWork W2146122122 @default.
• W2116098355 hasRelatedWork W2156749749 @default.
• W2116098355 hasRelatedWork W2493908366 @default.
• W2116098355 hasRelatedWork W2782546151 @default.
• W2116098355 hasRelatedWork W4241235718 @default.
• W2116098355 hasRelatedWork W4292485482 @default.
• W2116098355 hasRelatedWork W1700647254 @default.
• W2116098355 hasVolume "33" @default.
• W2116098355 isParatext "false" @default.
• W2116098355 isRetracted "false" @default.

• next