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- W2116711650 endingPage "1463" @default.
- W2116711650 startingPage "1454" @default.
- W2116711650 abstract "Stearoyl-CoA desaturase 1 (SCD-1) is a delta-9 fatty acid desaturase that catalyzes the synthesis of monounsaturated fatty acids. Indeed, SCD-1 is the critical control point regulating hepatic lipogenesis and lipid oxidation. Due to its central role in lipid metabolism in the liver, recent studies have focused on the involvement of SCD-1 in the development of fatty liver during obesity, diabetes mellitus, hypertension, excessive alcohol consumption, and in subjects with high triglyceride blood concentrations. The accumulation of fat in liver cells can be a sign that harmful conditions are developing, possibly associated with or leading to inflammation of the liver. This review evaluates the recent advances in our understanding of the regulation of SCD-1 expression and its role in the development of nonalcoholic and alcoholic hepatosteatosis. Animal models presenting a liver-specific loss or inhibition of SCD-1, as well as dietary interventions, have highlighted the important role of the enzyme in the accumulation of fat (fatty infiltration) in hepatocytes during both alcoholic and nonalcoholic liver diseases. The data summarized in this article support the notion that SCD-1 plays a direct role in the development of fatty liver diseases, and is not simply a marker of an unfavorable diet or hepatic disorder. Accordingly, SCD-1 represents a promising therapeutic target for the treatment of hepatic steatosis." @default.
- W2116711650 created "2016-06-24" @default.
- W2116711650 creator A5026527178 @default.
- W2116711650 creator A5036719913 @default.
- W2116711650 creator A5039076111 @default.
- W2116711650 creator A5047527603 @default.
- W2116711650 date "2012-10-01" @default.
- W2116711650 modified "2023-09-27" @default.
- W2116711650 title "Recent Advances on Stearoyl-Coa Desaturase Regulation in Fatty Liver Diseases" @default.
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