Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116716216> ?p ?o ?g. }
- W2116716216 endingPage "250" @default.
- W2116716216 startingPage "244" @default.
- W2116716216 abstract "OBJECTIVE: Schizophrenia is generally characterized by a progressive decline in functioning. Although structural brain abnormalities, particularly decrements in gray matter volume, are considered important to the pathology of schizophrenia, it is not resolved whether the brain abnormalities become more prominent over time. METHOD: Magnetic resonance brain images from 159 patients with schizophrenia and 158 healthy comparison subjects between 16 and 70 years of age were compared. Using linear regression analysis, the authors analyzed the relationship between the volumes of the total brain, gray and white matter, cerebellum, and lateral and third ventricles with patient age. RESULTS: Total brain (–2.2%), cerebral gray matter (–3.3%), prefrontal gray matter (–4.4%), and prefrontal white matter (–3.5%) volumes were smaller, and lateral (27%) and third (30%) ventricle and peripheral CSF (11%) volumes were larger in schizophrenia patients. A significant group-by-age interaction for gray matter volume was found, as shown by a steeper regression slope between age and gray matter volume in patients (–3.43 ml/year) than in healthy comparison subjects (–2.74 ml/year). CONCLUSIONS: The smaller brains of the patients with schizophrenia can be explained by decreases in gray matter volume. Moreover, the finding that the smaller gray matter volume was more pronounced in older patients with schizophrenia may suggest progressive loss of cerebral gray matter in schizophrenia patients." @default.
- W2116716216 created "2016-06-24" @default.
- W2116716216 creator A5001247088 @default.
- W2116716216 creator A5019398843 @default.
- W2116716216 creator A5030421132 @default.
- W2116716216 creator A5031613969 @default.
- W2116716216 creator A5053975836 @default.
- W2116716216 creator A5054762619 @default.
- W2116716216 creator A5062967626 @default.
- W2116716216 creator A5090337147 @default.
- W2116716216 date "2002-02-01" @default.
- W2116716216 modified "2023-10-16" @default.
- W2116716216 title "Volume Changes in Gray Matter in Patients With Schizophrenia" @default.
- W2116716216 cites W1493558168 @default.
- W2116716216 cites W1568392634 @default.
- W2116716216 cites W1657694742 @default.
- W2116716216 cites W1964388608 @default.
- W2116716216 cites W1965924747 @default.
- W2116716216 cites W1974702488 @default.
- W2116716216 cites W1976902101 @default.
- W2116716216 cites W1977014175 @default.
- W2116716216 cites W1977370225 @default.
- W2116716216 cites W1977410909 @default.
- W2116716216 cites W1980763739 @default.
- W2116716216 cites W1984111997 @default.
- W2116716216 cites W1990841563 @default.
- W2116716216 cites W1992790571 @default.
- W2116716216 cites W1993201831 @default.
- W2116716216 cites W1993773538 @default.
- W2116716216 cites W1995258695 @default.
- W2116716216 cites W2006942097 @default.
- W2116716216 cites W2008160685 @default.
- W2116716216 cites W2008873264 @default.
- W2116716216 cites W2010230693 @default.
- W2116716216 cites W2016312600 @default.
- W2116716216 cites W2019410645 @default.
- W2116716216 cites W2028693746 @default.
- W2116716216 cites W2030564379 @default.
- W2116716216 cites W2030913443 @default.
- W2116716216 cites W2034562813 @default.
- W2116716216 cites W2042976875 @default.
- W2116716216 cites W2045394963 @default.
- W2116716216 cites W2050797304 @default.
- W2116716216 cites W2054612454 @default.
- W2116716216 cites W2058093057 @default.
- W2116716216 cites W2058160425 @default.
- W2116716216 cites W2062956681 @default.
- W2116716216 cites W2067063559 @default.
- W2116716216 cites W2074354573 @default.
- W2116716216 cites W2080086149 @default.
- W2116716216 cites W2085756412 @default.
- W2116716216 cites W2088376011 @default.
- W2116716216 cites W2092749790 @default.
- W2116716216 cites W2092780744 @default.
- W2116716216 cites W2094301438 @default.
- W2116716216 cites W2094383054 @default.
- W2116716216 cites W2102405898 @default.
- W2116716216 cites W2102582359 @default.
- W2116716216 cites W2105224023 @default.
- W2116716216 cites W2116087808 @default.
- W2116716216 cites W2119821360 @default.
- W2116716216 cites W2126549748 @default.
- W2116716216 cites W2131426027 @default.
- W2116716216 cites W2131577940 @default.
- W2116716216 cites W2134789197 @default.
- W2116716216 cites W2135018545 @default.
- W2116716216 cites W2136148445 @default.
- W2116716216 cites W2146264275 @default.
- W2116716216 cites W2156123885 @default.
- W2116716216 cites W2269153022 @default.
- W2116716216 doi "https://doi.org/10.1176/appi.ajp.159.2.244" @default.
- W2116716216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11823266" @default.
- W2116716216 hasPublicationYear "2002" @default.
- W2116716216 type Work @default.
- W2116716216 sameAs 2116716216 @default.
- W2116716216 citedByCount "193" @default.
- W2116716216 countsByYear W21167162162012 @default.
- W2116716216 countsByYear W21167162162013 @default.
- W2116716216 countsByYear W21167162162014 @default.
- W2116716216 countsByYear W21167162162015 @default.
- W2116716216 countsByYear W21167162162016 @default.
- W2116716216 countsByYear W21167162162017 @default.
- W2116716216 countsByYear W21167162162018 @default.
- W2116716216 countsByYear W21167162162019 @default.
- W2116716216 countsByYear W21167162162020 @default.
- W2116716216 countsByYear W21167162162021 @default.
- W2116716216 countsByYear W21167162162022 @default.
- W2116716216 countsByYear W21167162162023 @default.
- W2116716216 crossrefType "journal-article" @default.
- W2116716216 hasAuthorship W2116716216A5001247088 @default.
- W2116716216 hasAuthorship W2116716216A5019398843 @default.
- W2116716216 hasAuthorship W2116716216A5030421132 @default.
- W2116716216 hasAuthorship W2116716216A5031613969 @default.
- W2116716216 hasAuthorship W2116716216A5053975836 @default.
- W2116716216 hasAuthorship W2116716216A5054762619 @default.
- W2116716216 hasAuthorship W2116716216A5062967626 @default.
- W2116716216 hasAuthorship W2116716216A5090337147 @default.
- W2116716216 hasConcept C118552586 @default.