Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116717371> ?p ?o ?g. }
- W2116717371 endingPage "13472" @default.
- W2116717371 startingPage "13467" @default.
- W2116717371 abstract "Significance MerR-family regulators act on suboptimal promoters to control the transcriptions of genes that help bacteria defend against a diverse set of metals and drugs. How they modulate RNA polymerase (RNAP) activity to control transcription initiation remains unclear, however. Here we show that CueR—a Cu + -responsive MerR-family metalloregulator—biases the kinetic sampling of RNAP binding events that lead to two noninterconverting states: a dead-end complex to repress or an open complex to activate transcription, constituting a branched pathway distinct from the linear pathway prevalent for transcription initiation at optimal promoters. This mechanistic insight contributes new fundamental knowledge to bacterial transcription regulation, and may help develop antibiotics that target this regulation mechanism to compromise bacterial defenses." @default.
- W2116717371 created "2016-06-24" @default.
- W2116717371 creator A5009759875 @default.
- W2116717371 creator A5013652689 @default.
- W2116717371 creator A5016572389 @default.
- W2116717371 creator A5032712331 @default.
- W2116717371 creator A5036662108 @default.
- W2116717371 creator A5049886131 @default.
- W2116717371 creator A5058622733 @default.
- W2116717371 creator A5077290711 @default.
- W2116717371 date "2015-10-19" @default.
- W2116717371 modified "2023-10-07" @default.
- W2116717371 title "Metalloregulator CueR biases RNA polymerase’s kinetic sampling of dead-end or open complex to repress or activate transcription" @default.
- W2116717371 cites W106223738 @default.
- W2116717371 cites W1479890676 @default.
- W2116717371 cites W1515974038 @default.
- W2116717371 cites W1582561186 @default.
- W2116717371 cites W1586917242 @default.
- W2116717371 cites W1964767569 @default.
- W2116717371 cites W1968366930 @default.
- W2116717371 cites W1968877792 @default.
- W2116717371 cites W1969511411 @default.
- W2116717371 cites W1970199039 @default.
- W2116717371 cites W1982418026 @default.
- W2116717371 cites W1994265058 @default.
- W2116717371 cites W1999570631 @default.
- W2116717371 cites W2024828640 @default.
- W2116717371 cites W2028782340 @default.
- W2116717371 cites W2031395135 @default.
- W2116717371 cites W2045300018 @default.
- W2116717371 cites W2046228091 @default.
- W2116717371 cites W2052094781 @default.
- W2116717371 cites W2078868084 @default.
- W2116717371 cites W2080131435 @default.
- W2116717371 cites W2093471356 @default.
- W2116717371 cites W2097270286 @default.
- W2116717371 cites W2107921073 @default.
- W2116717371 cites W2118823919 @default.
- W2116717371 cites W2119076989 @default.
- W2116717371 cites W2125132050 @default.
- W2116717371 cites W2130512803 @default.
- W2116717371 cites W2135054636 @default.
- W2116717371 cites W2140803417 @default.
- W2116717371 cites W2140840449 @default.
- W2116717371 cites W2147431408 @default.
- W2116717371 cites W2152293733 @default.
- W2116717371 cites W2159945949 @default.
- W2116717371 cites W2161407287 @default.
- W2116717371 cites W2165920356 @default.
- W2116717371 cites W2327961582 @default.
- W2116717371 cites W2411123121 @default.
- W2116717371 doi "https://doi.org/10.1073/pnas.1515231112" @default.
- W2116717371 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4640755" @default.
- W2116717371 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26483469" @default.
- W2116717371 hasPublicationYear "2015" @default.
- W2116717371 type Work @default.
- W2116717371 sameAs 2116717371 @default.
- W2116717371 citedByCount "29" @default.
- W2116717371 countsByYear W21167173712016 @default.
- W2116717371 countsByYear W21167173712017 @default.
- W2116717371 countsByYear W21167173712019 @default.
- W2116717371 countsByYear W21167173712020 @default.
- W2116717371 countsByYear W21167173712021 @default.
- W2116717371 countsByYear W21167173712022 @default.
- W2116717371 countsByYear W21167173712023 @default.
- W2116717371 crossrefType "journal-article" @default.
- W2116717371 hasAuthorship W2116717371A5009759875 @default.
- W2116717371 hasAuthorship W2116717371A5013652689 @default.
- W2116717371 hasAuthorship W2116717371A5016572389 @default.
- W2116717371 hasAuthorship W2116717371A5032712331 @default.
- W2116717371 hasAuthorship W2116717371A5036662108 @default.
- W2116717371 hasAuthorship W2116717371A5049886131 @default.
- W2116717371 hasAuthorship W2116717371A5058622733 @default.
- W2116717371 hasAuthorship W2116717371A5077290711 @default.
- W2116717371 hasBestOaLocation W21167173711 @default.
- W2116717371 hasConcept C101762097 @default.
- W2116717371 hasConcept C104317684 @default.
- W2116717371 hasConcept C138885662 @default.
- W2116717371 hasConcept C150194340 @default.
- W2116717371 hasConcept C179926584 @default.
- W2116717371 hasConcept C26261996 @default.
- W2116717371 hasConcept C2776449523 @default.
- W2116717371 hasConcept C41895202 @default.
- W2116717371 hasConcept C54355233 @default.
- W2116717371 hasConcept C64350747 @default.
- W2116717371 hasConcept C67705224 @default.
- W2116717371 hasConcept C70721500 @default.
- W2116717371 hasConcept C82381507 @default.
- W2116717371 hasConcept C86803240 @default.
- W2116717371 hasConcept C95444343 @default.
- W2116717371 hasConceptScore W2116717371C101762097 @default.
- W2116717371 hasConceptScore W2116717371C104317684 @default.
- W2116717371 hasConceptScore W2116717371C138885662 @default.
- W2116717371 hasConceptScore W2116717371C150194340 @default.
- W2116717371 hasConceptScore W2116717371C179926584 @default.
- W2116717371 hasConceptScore W2116717371C26261996 @default.
- W2116717371 hasConceptScore W2116717371C2776449523 @default.
- W2116717371 hasConceptScore W2116717371C41895202 @default.