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• W2116719149 endingPage "2031" @default.
• W2116719149 startingPage "2026" @default.
• W2116719149 abstract "Clinical trials with statins have demonstrated significant reductions in cardiovascular events. Remnant lipoproteins are independent predictors of cardiovascular events. Because of the paucity of data on the effect of statins on remnant lipoproteins, we tested the effect of pravastatin, simvastatin, and atorvastatin on remnant lipoprotein cholesterol (RLP-C) levels in a randomized crossover study in patients with combined hyperlipidemia. After a 6-week diet phase, patients (n=22) were randomized to pravastatin (40 mg/d), simvastatin (20 mg/d), or atorvastatin (10 mg/d) for 6 weeks, with a 3-week washout between each drug. All 3 drugs significantly decreased total and low density lipoprotein (LDL) cholesterol ( P <0.001). Mean reduction in LDL cholesterol with pravastatin, simvastatin, and atorvastatin was 21%, 29%, and 32%, respectively. None of the drugs affected high density lipoprotein cholesterol levels. Median levels of triglycerides were significantly reduced with simvastatin (26%, P =0.001) and atorvastatin (24%, P =0.0001) but not with pravastatin (9%, P =0.18). Non–high density lipoprotein cholesterol decreased significantly with all 3 statins (20%, 29%, and 32% with pravastatin, simvastatin, and atorvastatin, respectively; P <0.001). Median RLP-C levels were significantly reduced with simvastatin (6%, P <0.05) and atorvastatin (25.9%, P <0.001) but not with pravastatin (2.9%, P =0.58). Thus, atorvastatin and simvastatin, in addition to reducing LDL cholesterol and triglyceride levels, significantly reduced RLP-C levels. This could be another potential mechanism to explain their cardiovascular benefits." @default.
• W2116719149 created "2016-06-24" @default.
• W2116719149 creator A5011782005 @default.
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• W2116719149 date "2001-12-01" @default.
• W2116719149 modified "2023-10-16" @default.
• W2116719149 title "Effect of Statin Therapy on Remnant Lipoprotein Cholesterol Levels in Patients With Combined Hyperlipidemia" @default.
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• W2116719149 doi "https://doi.org/10.1161/hq1201.100259" @default.
• W2116719149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11742880" @default.
• W2116719149 hasPublicationYear "2001" @default.
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