FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116722071> ?p ?o ?g. }

• W2116722071 endingPage "1063" @default.
• W2116722071 startingPage "1057" @default.
• W2116722071 abstract "The antibiotic salinomycin (Salin) was recently identified as an antitumor drug for the treatment of several types of solid tumors. However, the effects of Salin on the migratory and invasive properties of hepatocellular carcinoma (HCC) cells are unclear. The present study aimed to determine the antitumor efficacy and mechanism of Salin in HCC cells. Human HCC cells (HCCLM3) treated with Salin showed a concentration-dependent reduction in cell migration and invasion, and this was associated with reduced MMP9 expression. The MMP9 promoter and enhancer in a luciferase reporter assay revealed that Salin can regulate MMP9 expression through an activator protein (AP-1) site within the MMP9 enhancer. JunD, one of the AP-1 components, was significantly decreased by Salin in a concentration- and time-dependent manner. Salin was able to induce c-Jun NH2-kinase (JNK) phosphorylation and to block both JunD and MMP9 expression. Our results showed that JNK phosphorylation and JunD may be involved in the Salin-regulated MMP9 signaling pathway in HCCLM3 cells and may mediate HCC cell biological characteristics. Our studies provide new insight into the antitumor effects of Salin." @default.
• W2116722071 created "2016-06-24" @default.
• W2116722071 creator A5015114505 @default.
• W2116722071 creator A5031801474 @default.
• W2116722071 creator A5046571222 @default.
• W2116722071 creator A5048077073 @default.
• W2116722071 creator A5054603016 @default.
• W2116722071 creator A5068080767 @default.
• W2116722071 creator A5088167158 @default.
• W2116722071 date "2014-12-18" @default.
• W2116722071 modified "2023-09-29" @default.
• W2116722071 title "Salinomycin inhibits hepatocellular carcinoma cell invasion and migration through JNK/JunD pathway-mediated MMP9 expression" @default.
• W2116722071 cites W1983082314 @default.
• W2116722071 cites W1983889487 @default.
• W2116722071 cites W1992017365 @default.
• W2116722071 cites W1997249253 @default.
• W2116722071 cites W2021844359 @default.
• W2116722071 cites W2030697697 @default.
• W2116722071 cites W2037525343 @default.
• W2116722071 cites W2038186927 @default.
• W2116722071 cites W2041036867 @default.
• W2116722071 cites W2044091148 @default.
• W2116722071 cites W2058456997 @default.
• W2116722071 cites W2075466369 @default.
• W2116722071 cites W2080840041 @default.
• W2116722071 cites W2084590325 @default.
• W2116722071 cites W2086351434 @default.
• W2116722071 cites W2088667932 @default.
• W2116722071 cites W2106787323 @default.
• W2116722071 cites W2149342916 @default.
• W2116722071 cites W2158272128 @default.
• W2116722071 cites W2168550266 @default.
• W2116722071 doi "https://doi.org/10.3892/or.2014.3680" @default.
• W2116722071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4324482" @default.
• W2116722071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25522777" @default.
• W2116722071 hasPublicationYear "2014" @default.
• W2116722071 type Work @default.
• W2116722071 sameAs 2116722071 @default.
• W2116722071 citedByCount "12" @default.
• W2116722071 countsByYear W21167220712016 @default.
• W2116722071 countsByYear W21167220712017 @default.
• W2116722071 countsByYear W21167220712018 @default.
• W2116722071 countsByYear W21167220712019 @default.
• W2116722071 countsByYear W21167220712021 @default.
• W2116722071 countsByYear W21167220712022 @default.
• W2116722071 crossrefType "journal-article" @default.
• W2116722071 hasAuthorship W2116722071A5015114505 @default.
• W2116722071 hasAuthorship W2116722071A5031801474 @default.
• W2116722071 hasAuthorship W2116722071A5046571222 @default.
• W2116722071 hasAuthorship W2116722071A5048077073 @default.
• W2116722071 hasAuthorship W2116722071A5054603016 @default.
• W2116722071 hasAuthorship W2116722071A5068080767 @default.
• W2116722071 hasAuthorship W2116722071A5088167158 @default.
• W2116722071 hasBestOaLocation W21167220711 @default.
• W2116722071 hasConcept C104317684 @default.
• W2116722071 hasConcept C111936080 @default.
• W2116722071 hasConcept C11960822 @default.
• W2116722071 hasConcept C127561419 @default.
• W2116722071 hasConcept C1491633281 @default.
• W2116722071 hasConcept C150194340 @default.
• W2116722071 hasConcept C190283241 @default.
• W2116722071 hasConcept C2775997469 @default.
• W2116722071 hasConcept C2778019345 @default.
• W2116722071 hasConcept C2781018059 @default.
• W2116722071 hasConcept C29537977 @default.
• W2116722071 hasConcept C502942594 @default.
• W2116722071 hasConcept C54009773 @default.
• W2116722071 hasConcept C54355233 @default.
• W2116722071 hasConcept C55493867 @default.
• W2116722071 hasConcept C62112901 @default.
• W2116722071 hasConcept C81885089 @default.
• W2116722071 hasConcept C86803240 @default.
• W2116722071 hasConcept C95444343 @default.
• W2116722071 hasConceptScore W2116722071C104317684 @default.
• W2116722071 hasConceptScore W2116722071C111936080 @default.
• W2116722071 hasConceptScore W2116722071C11960822 @default.
• W2116722071 hasConceptScore W2116722071C127561419 @default.
• W2116722071 hasConceptScore W2116722071C1491633281 @default.
• W2116722071 hasConceptScore W2116722071C150194340 @default.
• W2116722071 hasConceptScore W2116722071C190283241 @default.
• W2116722071 hasConceptScore W2116722071C2775997469 @default.
• W2116722071 hasConceptScore W2116722071C2778019345 @default.
• W2116722071 hasConceptScore W2116722071C2781018059 @default.
• W2116722071 hasConceptScore W2116722071C29537977 @default.
• W2116722071 hasConceptScore W2116722071C502942594 @default.
• W2116722071 hasConceptScore W2116722071C54009773 @default.
• W2116722071 hasConceptScore W2116722071C54355233 @default.
• W2116722071 hasConceptScore W2116722071C55493867 @default.
• W2116722071 hasConceptScore W2116722071C62112901 @default.
• W2116722071 hasConceptScore W2116722071C81885089 @default.
• W2116722071 hasConceptScore W2116722071C86803240 @default.
• W2116722071 hasConceptScore W2116722071C95444343 @default.
• W2116722071 hasIssue "3" @default.
• W2116722071 hasLocation W21167220711 @default.
• W2116722071 hasLocation W21167220712 @default.
• W2116722071 hasLocation W21167220713 @default.
• W2116722071 hasLocation W21167220714 @default.
• W2116722071 hasOpenAccess W2116722071 @default.

• next