Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116739513> ?p ?o ?g. }
- W2116739513 endingPage "2097" @default.
- W2116739513 startingPage "2080" @default.
- W2116739513 abstract "The Golgi complex and ER are dynamically connected by anterograde and retrograde trafficking pathways. To what extent and by what mechanism outward-bound cargo proteins escape retrograde trafficking has been poorly investigated. Here, we analysed the behaviour of several membrane proteins at the ER/Golgi interface in live cells. When Golgi-to-plasma membrane transport was blocked, vesicular stomatitis virus glycoprotein (VSVG), which bears an ER export signal, accumulated in the Golgi, whereas an export signal-deleted version of VSVG attained a steady state determined by the balance of retrograde and anterograde traffic. A similar behaviour was displayed by EGF receptor and by a model tail-anchored protein, whose retrograde traffic was slowed by addition of VSVG's export signal. Retrograde trafficking was energy- and Rab6-dependent, and Rab6 inhibition accelerated signal-deleted VSVG's transport to the cell surface. Our results extend the dynamic bi-directional relationship between the Golgi and ER to include surface-directed proteins, uncover an unanticipated role for export signals at the Golgi complex, and identify recycling as a novel factor that regulates cargo transport out of the early secretory pathway." @default.
- W2116739513 created "2016-06-24" @default.
- W2116739513 creator A5046304056 @default.
- W2116739513 creator A5063264447 @default.
- W2116739513 creator A5072524565 @default.
- W2116739513 date "2014-07-25" @default.
- W2116739513 modified "2023-10-18" @default.
- W2116739513 title "A positive signal prevents secretory membrane cargo from recycling between the Golgi and the <scp>ER</scp>" @default.
- W2116739513 cites W1481922413 @default.
- W2116739513 cites W1526795140 @default.
- W2116739513 cites W1531431198 @default.
- W2116739513 cites W1548266878 @default.
- W2116739513 cites W1567136101 @default.
- W2116739513 cites W1749731407 @default.
- W2116739513 cites W1897848314 @default.
- W2116739513 cites W1965381942 @default.
- W2116739513 cites W1965924665 @default.
- W2116739513 cites W1970472689 @default.
- W2116739513 cites W1972796001 @default.
- W2116739513 cites W1977904734 @default.
- W2116739513 cites W1982675242 @default.
- W2116739513 cites W1986429697 @default.
- W2116739513 cites W1991868625 @default.
- W2116739513 cites W1994624166 @default.
- W2116739513 cites W1997223018 @default.
- W2116739513 cites W2009530990 @default.
- W2116739513 cites W2010378383 @default.
- W2116739513 cites W2011727356 @default.
- W2116739513 cites W2012040490 @default.
- W2116739513 cites W2017023549 @default.
- W2116739513 cites W2026638402 @default.
- W2116739513 cites W2032504743 @default.
- W2116739513 cites W2035807916 @default.
- W2116739513 cites W2045571454 @default.
- W2116739513 cites W2054459441 @default.
- W2116739513 cites W2054593368 @default.
- W2116739513 cites W2060528642 @default.
- W2116739513 cites W2068194010 @default.
- W2116739513 cites W2078425701 @default.
- W2116739513 cites W2086360580 @default.
- W2116739513 cites W2088337203 @default.
- W2116739513 cites W2095276872 @default.
- W2116739513 cites W2096678905 @default.
- W2116739513 cites W2096868964 @default.
- W2116739513 cites W2097020042 @default.
- W2116739513 cites W2107312415 @default.
- W2116739513 cites W2113736802 @default.
- W2116739513 cites W2126325985 @default.
- W2116739513 cites W2135736561 @default.
- W2116739513 cites W2141857608 @default.
- W2116739513 cites W2143095999 @default.
- W2116739513 cites W2146568672 @default.
- W2116739513 cites W2148342654 @default.
- W2116739513 cites W2157759988 @default.
- W2116739513 cites W2168375114 @default.
- W2116739513 cites W2171743890 @default.
- W2116739513 cites W2242039608 @default.
- W2116739513 cites W2402354430 @default.
- W2116739513 doi "https://doi.org/10.15252/embj.201488367" @default.
- W2116739513 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4195774" @default.
- W2116739513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25063674" @default.
- W2116739513 hasPublicationYear "2014" @default.
- W2116739513 type Work @default.
- W2116739513 sameAs 2116739513 @default.
- W2116739513 citedByCount "19" @default.
- W2116739513 countsByYear W21167395132014 @default.
- W2116739513 countsByYear W21167395132015 @default.
- W2116739513 countsByYear W21167395132016 @default.
- W2116739513 countsByYear W21167395132017 @default.
- W2116739513 countsByYear W21167395132018 @default.
- W2116739513 countsByYear W21167395132019 @default.
- W2116739513 countsByYear W21167395132020 @default.
- W2116739513 countsByYear W21167395132021 @default.
- W2116739513 countsByYear W21167395132022 @default.
- W2116739513 countsByYear W21167395132023 @default.
- W2116739513 crossrefType "journal-article" @default.
- W2116739513 hasAuthorship W2116739513A5046304056 @default.
- W2116739513 hasAuthorship W2116739513A5063264447 @default.
- W2116739513 hasAuthorship W2116739513A5072524565 @default.
- W2116739513 hasBestOaLocation W21167395132 @default.
- W2116739513 hasConcept C104317684 @default.
- W2116739513 hasConcept C10858879 @default.
- W2116739513 hasConcept C119062480 @default.
- W2116739513 hasConcept C156399914 @default.
- W2116739513 hasConcept C158617107 @default.
- W2116739513 hasConcept C167625842 @default.
- W2116739513 hasConcept C203014093 @default.
- W2116739513 hasConcept C2522874641 @default.
- W2116739513 hasConcept C2779057330 @default.
- W2116739513 hasConcept C49039625 @default.
- W2116739513 hasConcept C55493867 @default.
- W2116739513 hasConcept C57581600 @default.
- W2116739513 hasConcept C62478195 @default.
- W2116739513 hasConcept C6492254 @default.
- W2116739513 hasConcept C70192387 @default.
- W2116739513 hasConcept C86803240 @default.
- W2116739513 hasConcept C95444343 @default.
- W2116739513 hasConceptScore W2116739513C104317684 @default.