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• W2116741676 abstract "Malaria is caused by obligate intracellular parasites, of which Plasmodium falciparum is the most lethal species. In humans, P. falciparum merozoites (invasive forms of the parasite) employ a host of parasite proteins to rapidly invade erythrocytes. One of these is the P. falciparum apical membrane antigen 1 (PfAMA1) which forms a complex with rhoptry neck proteins at the tight junction. Here, we have placed the Pfama1 gene under conditional control using dimerizable Cre recombinase (DiCre) in P. falciparum. DiCre-mediated excision of the loxP-flanked Pfama1 gene results in approximately 80% decreased expression of the protein within one intraerythrocytic growth cycle. This reduces growth by 40%, due to decreased invasion efficiency characterized by a post-invasion defect in sealing of the parasitophorous vacuole. These results show that PfAMA1 is an essential protein for merozoite invasion in P. falciparum and either directly or indirectly plays a role in resealing of the red blood cell at the posterior end of the invasion event." @default.
• W2116741676 created "2016-06-24" @default.
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• W2116741676 date "2014-03-27" @default.
• W2116741676 modified "2023-09-30" @default.
• W2116741676 title "Conditional expression of apical membrane antigen 1 in <scp> <i>P</i> </scp> <i>lasmodium falciparum</i> shows it is required for erythrocyte invasion by merozoites" @default.
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• W2116741676 doi "https://doi.org/10.1111/cmi.12287" @default.
• W2116741676 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4231980" @default.
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