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- W2116742406 abstract "To the Editor: Systemic sclerosis (SSc) is a severe autoimmune condition characterized by both fibrotic and vascular complications. This can progress to functionally devastating subcutaneous fibrosis, as well as death from pulmonary, cardiac, renal, or gastrointestinal (GI) involvement1. High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (HSCT) is the first therapy to show evidence of clinically significant improvement in skin and lung function as well as quality of life in SSc when compared to intravenous cyclophosphamide (CYC)2. The multi-center, phase III randomized trial, Autologous Stem Cell Transplantation International Scleroderma, also showed a significant benefit in longterm, event-free survival with autologous HSCT compared to CYC, despite a higher early treatment-related mortality3. A publication from the European Group for Blood and Marrow transplantation (EBMT) has updated guidelines for autologous HSCT in autoimmune diseases, including SSc4. GI involvement is the presenting feature of the disease … Address correspondence to Dr. A. Bhattacharyya, St. Vincent’s Hospital, Haematology, 390 Victoria St., Sydney, New South Wales 2010, Australia. E-mail: abir123{at}gmail.com" @default.
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- W2116742406 date "2015-03-01" @default.
- W2116742406 modified "2023-10-13" @default.
- W2116742406 title "Autologous Hematopoietic Stem Cell Transplant for Systemic Sclerosis Improves Anemia from Gastric Antral Vascular Ectasia" @default.
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- W2116742406 doi "https://doi.org/10.3899/jrheum.141234" @default.
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