Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116746228> ?p ?o ?g. }
- W2116746228 abstract "We have conducted three studies to examine the role of TNFalpha in islet destruction in female nonobese diabetic mouse (NOD) mice, a model of human autoimmune diabetes, using polyethylene glycolated (PEGylated) soluble TNF receptor type I (PEG sTNF-RI) as TNFalpha antagonist. PEG sTNF-RI (3 mg/kg, sc) was given every other day to NOD mice from age wk 8 for 12 wk (study 1), from age wk 12 for 8 wk (study 2), or from age wk 8 for 3 wk, with cyclophosphamide (6 mg/mouse) injected at wk 9 to accelerate the onset of diabetes (study 3). Diabetic incidence was reduced (control vs. PEG sTNF-RI) from 68.7% (11 of 16) to 18.3% (3 of 16) in study 1, from 84.6% (11 of 13) to 28.5% (4 of 14) in study 2, and from 66.6% (8 of 12) to 23.1% (3 of 13) in study 3, respectively. The incidence of insulitis was also reduced from 91.6% (11 of 12) to 12.5% (2 of 16) in study 1 and from 100% (7 of 7) to 16.6% (2 of 12) in study 2 by PEG sTNF-RI. PEG sTNF-RI also largely preserved islet insulin content, reduced mRNA of inducible nitric oxide synthase and IL-6 in pancreases, and lowered plasma corticosterone, glycerol, and free fatty acid levels. These results confirm a pathogenic role of TNFalpha in mediating insulitis in NOD mice and suggest the prophylactic and therapeutic potential of PEG sTNF-RI for human autoimmune diabetes." @default.
- W2116746228 created "2016-06-24" @default.
- W2116746228 creator A5029403937 @default.
- W2116746228 creator A5040227989 @default.
- W2116746228 creator A5054680792 @default.
- W2116746228 creator A5055553464 @default.
- W2116746228 creator A5057269007 @default.
- W2116746228 creator A5083440306 @default.
- W2116746228 creator A5084199482 @default.
- W2116746228 date "2002-09-01" @default.
- W2116746228 modified "2023-09-27" @default.
- W2116746228 title "Polyethylene Glycolated Recombinant TNF Receptor I Improves Insulitis and Reduces Incidence of Spontaneous and Cyclophosphamide-Accelerated Diabetes in Nonobese Diabetic Mice" @default.
- W2116746228 cites W1570066979 @default.
- W2116746228 cites W1576688622 @default.
- W2116746228 cites W1970765576 @default.
- W2116746228 cites W1972118176 @default.
- W2116746228 cites W1972272933 @default.
- W2116746228 cites W1973672167 @default.
- W2116746228 cites W1980093190 @default.
- W2116746228 cites W1981962083 @default.
- W2116746228 cites W1982970462 @default.
- W2116746228 cites W2012487047 @default.
- W2116746228 cites W2021714442 @default.
- W2116746228 cites W2022172040 @default.
- W2116746228 cites W2050473688 @default.
- W2116746228 cites W2056707218 @default.
- W2116746228 cites W2056782128 @default.
- W2116746228 cites W2058857909 @default.
- W2116746228 cites W2059353746 @default.
- W2116746228 cites W2077577428 @default.
- W2116746228 cites W2084353045 @default.
- W2116746228 cites W2092512708 @default.
- W2116746228 cites W2099354064 @default.
- W2116746228 cites W2101987890 @default.
- W2116746228 cites W2110061490 @default.
- W2116746228 cites W2118843477 @default.
- W2116746228 cites W2123244699 @default.
- W2116746228 cites W2130322554 @default.
- W2116746228 cites W2131699209 @default.
- W2116746228 cites W2138343247 @default.
- W2116746228 cites W2141335997 @default.
- W2116746228 cites W2142678320 @default.
- W2116746228 cites W2144540208 @default.
- W2116746228 cites W2145591227 @default.
- W2116746228 cites W2146786154 @default.
- W2116746228 cites W2150571795 @default.
- W2116746228 cites W2160247338 @default.
- W2116746228 cites W2164924638 @default.
- W2116746228 cites W2336449142 @default.
- W2116746228 cites W2403451126 @default.
- W2116746228 cites W2412335453 @default.
- W2116746228 cites W2416121270 @default.
- W2116746228 cites W2461550124 @default.
- W2116746228 cites W2606827166 @default.
- W2116746228 cites W362899284 @default.
- W2116746228 doi "https://doi.org/10.1210/en.2002-220412" @default.
- W2116746228 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12193562" @default.
- W2116746228 hasPublicationYear "2002" @default.
- W2116746228 type Work @default.
- W2116746228 sameAs 2116746228 @default.
- W2116746228 citedByCount "12" @default.
- W2116746228 countsByYear W21167462282012 @default.
- W2116746228 countsByYear W21167462282014 @default.
- W2116746228 countsByYear W21167462282015 @default.
- W2116746228 countsByYear W21167462282016 @default.
- W2116746228 countsByYear W21167462282017 @default.
- W2116746228 crossrefType "journal-article" @default.
- W2116746228 hasAuthorship W2116746228A5029403937 @default.
- W2116746228 hasAuthorship W2116746228A5040227989 @default.
- W2116746228 hasAuthorship W2116746228A5054680792 @default.
- W2116746228 hasAuthorship W2116746228A5055553464 @default.
- W2116746228 hasAuthorship W2116746228A5057269007 @default.
- W2116746228 hasAuthorship W2116746228A5083440306 @default.
- W2116746228 hasAuthorship W2116746228A5084199482 @default.
- W2116746228 hasBestOaLocation W21167462281 @default.
- W2116746228 hasConcept C10138342 @default.
- W2116746228 hasConcept C126322002 @default.
- W2116746228 hasConcept C134018914 @default.
- W2116746228 hasConcept C162324750 @default.
- W2116746228 hasConcept C165220095 @default.
- W2116746228 hasConcept C203014093 @default.
- W2116746228 hasConcept C2776694085 @default.
- W2116746228 hasConcept C2776755627 @default.
- W2116746228 hasConcept C2778013207 @default.
- W2116746228 hasConcept C2779306644 @default.
- W2116746228 hasConcept C2779511750 @default.
- W2116746228 hasConcept C54400483 @default.
- W2116746228 hasConcept C555293320 @default.
- W2116746228 hasConcept C55851684 @default.
- W2116746228 hasConcept C71924100 @default.
- W2116746228 hasConceptScore W2116746228C10138342 @default.
- W2116746228 hasConceptScore W2116746228C126322002 @default.
- W2116746228 hasConceptScore W2116746228C134018914 @default.
- W2116746228 hasConceptScore W2116746228C162324750 @default.
- W2116746228 hasConceptScore W2116746228C165220095 @default.
- W2116746228 hasConceptScore W2116746228C203014093 @default.
- W2116746228 hasConceptScore W2116746228C2776694085 @default.
- W2116746228 hasConceptScore W2116746228C2776755627 @default.
- W2116746228 hasConceptScore W2116746228C2778013207 @default.
- W2116746228 hasConceptScore W2116746228C2779306644 @default.