FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2116747012> ?p ?o ?g. }

• W2116747012 endingPage "2114" @default.
• W2116747012 startingPage "2109" @default.
• W2116747012 abstract "An important unmet experimental objective is to analyze local RNA structure in a way that is strictly governed by solvent accessibility. Essentially all chemical probes currently used to evaluate RNA (and DNA) structure via formation of stable covalent adducts employ carbon-based electrophiles, which undergo nucleophilic attack from limited spatial orientations and via highly polar transition states. Reaction by these classical electrophiles is therefore gated by both solvent accessibility and additional electrostatic factors. In contrast, silicon electrophiles react via their d-orbitals and consequently can undergo nucleophilic attack from many spatial orientations. In this work, we explore the use of silanes to react indiscriminately with RNA such that the primary factor governing reactivity is solvent accessibility. We show that N,N-(dimethylamino)dimethylchlorosilane (DMAS-Cl) reacts at the guanosine N2 position to yield a near-perfect measure (r ≥ 0.82) of solvent accessibility in an RNA with a complex tertiary structure. This silane-based chemistry represents a direct and quantitative approach for probing solvent accessibility at the base pairing face of guanosine in RNA." @default.
• W2116747012 created "2016-06-24" @default.
• W2116747012 creator A5012163499 @default.
• W2116747012 creator A5050389355 @default.
• W2116747012 creator A5057695381 @default.
• W2116747012 date "2009-02-18" @default.
• W2116747012 modified "2023-09-24" @default.
• W2116747012 title "Quantitative Analysis of RNA Solvent Accessibility by N-Silylation of Guanosine" @default.
• W2116747012 cites W1486369891 @default.
• W2116747012 cites W1585813307 @default.
• W2116747012 cites W1972533328 @default.
• W2116747012 cites W1975329612 @default.
• W2116747012 cites W1984072183 @default.
• W2116747012 cites W1988018659 @default.
• W2116747012 cites W1988884185 @default.
• W2116747012 cites W1995017064 @default.
• W2116747012 cites W1996608836 @default.
• W2116747012 cites W2005756919 @default.
• W2116747012 cites W2044247083 @default.
• W2116747012 cites W2044410490 @default.
• W2116747012 cites W2055104860 @default.
• W2116747012 cites W2056975726 @default.
• W2116747012 cites W2060026013 @default.
• W2116747012 cites W2065841577 @default.
• W2116747012 cites W2081451822 @default.
• W2116747012 cites W2086404667 @default.
• W2116747012 cites W2106462936 @default.
• W2116747012 cites W2106478835 @default.
• W2116747012 cites W2107363367 @default.
• W2116747012 cites W2118688581 @default.
• W2116747012 cites W2120974004 @default.
• W2116747012 cites W2124555115 @default.
• W2116747012 cites W2134036931 @default.
• W2116747012 cites W2142624055 @default.
• W2116747012 cites W2151596277 @default.
• W2116747012 cites W2160568246 @default.
• W2116747012 cites W2171643158 @default.
• W2116747012 cites W4206761288 @default.
• W2116747012 cites W76658770 @default.
• W2116747012 cites W983487374 @default.
• W2116747012 doi "https://doi.org/10.1021/bi801939g" @default.
• W2116747012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19226117" @default.
• W2116747012 hasPublicationYear "2009" @default.
• W2116747012 type Work @default.
• W2116747012 sameAs 2116747012 @default.
• W2116747012 citedByCount "19" @default.
• W2116747012 countsByYear W21167470122013 @default.
• W2116747012 countsByYear W21167470122014 @default.
• W2116747012 countsByYear W21167470122015 @default.
• W2116747012 countsByYear W21167470122016 @default.
• W2116747012 countsByYear W21167470122017 @default.
• W2116747012 countsByYear W21167470122018 @default.
• W2116747012 countsByYear W21167470122020 @default.
• W2116747012 countsByYear W21167470122022 @default.
• W2116747012 countsByYear W21167470122023 @default.
• W2116747012 crossrefType "journal-article" @default.
• W2116747012 hasAuthorship W2116747012A5012163499 @default.
• W2116747012 hasAuthorship W2116747012A5050389355 @default.
• W2116747012 hasAuthorship W2116747012A5057695381 @default.
• W2116747012 hasConcept C104317684 @default.
• W2116747012 hasConcept C126142528 @default.
• W2116747012 hasConcept C142724271 @default.
• W2116747012 hasConcept C161790260 @default.
• W2116747012 hasConcept C178790620 @default.
• W2116747012 hasConcept C178907741 @default.
• W2116747012 hasConcept C185592680 @default.
• W2116747012 hasConcept C204787440 @default.
• W2116747012 hasConcept C2776910235 @default.
• W2116747012 hasConcept C2777995097 @default.
• W2116747012 hasConcept C2780471494 @default.
• W2116747012 hasConcept C50027330 @default.
• W2116747012 hasConcept C5304478 @default.
• W2116747012 hasConcept C55493867 @default.
• W2116747012 hasConcept C67705224 @default.
• W2116747012 hasConcept C71924100 @default.
• W2116747012 hasConceptScore W2116747012C104317684 @default.
• W2116747012 hasConceptScore W2116747012C126142528 @default.
• W2116747012 hasConceptScore W2116747012C142724271 @default.
• W2116747012 hasConceptScore W2116747012C161790260 @default.
• W2116747012 hasConceptScore W2116747012C178790620 @default.
• W2116747012 hasConceptScore W2116747012C178907741 @default.
• W2116747012 hasConceptScore W2116747012C185592680 @default.
• W2116747012 hasConceptScore W2116747012C204787440 @default.
• W2116747012 hasConceptScore W2116747012C2776910235 @default.
• W2116747012 hasConceptScore W2116747012C2777995097 @default.
• W2116747012 hasConceptScore W2116747012C2780471494 @default.
• W2116747012 hasConceptScore W2116747012C50027330 @default.
• W2116747012 hasConceptScore W2116747012C5304478 @default.
• W2116747012 hasConceptScore W2116747012C55493867 @default.
• W2116747012 hasConceptScore W2116747012C67705224 @default.
• W2116747012 hasConceptScore W2116747012C71924100 @default.
• W2116747012 hasIssue "10" @default.
• W2116747012 hasLocation W21167470121 @default.
• W2116747012 hasLocation W21167470122 @default.
• W2116747012 hasOpenAccess W2116747012 @default.
• W2116747012 hasPrimaryLocation W21167470121 @default.
• W2116747012 hasRelatedWork W1990165371 @default.
• W2116747012 hasRelatedWork W2094142780 @default.

• next