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• W2116747718 abstract "During pregnancy, a lot of stresses are experienced, caused by decrease in macro and micronutrients, changes in plasma volume, tissue hypoxia and disease conditions like malaria, helminthiasis, HIV, diabetes, hypertension etc. Earlier reports indicate that asymptomatic malaria parasitemia does not induce additional oxidative stress during pregnancy. This study aims to find whether symptomatic malaria parasitemia causes additional oxidative stress on pregnant women. It is a cross-sectional study involving 119 febrile pregnant women attending antenatal clinics of some hospitals in a malaria endemic town of Enugu, Enugu State of Nigeria. They were aged between 24 and 36 years, and mainly in their second (14 - 28 weeks) and third (29 weeks and above) trimesters of pregnancy. Malaria density was estimated by absolute malaria count, while antioxidant minerals - copper, manganese, selenium and zinc were determined using atomic absorption spectrophotometer. Results obtained for negative, mild and moderate malaria densities were 1.36±0.78mg/dL, 1.44±0.65mg/dL and 1.69±0.68mg/dL for copper; 0.60±0.53mg/dL 0.53±0.43mg/dL and 0.31±0.26mg/dL for manganese; 78.93±16.63µg/dL, 95.55±19.86µg/dL and 98.16±12.41µg/dL for selenium; and 2.69±1.33mg/dL, 2.74±0.81mg/dL and 2.90±0.76mg/dL for zinc. Analysis of variance indicates that copper and zinc showed no significant changes as malaria density increased (p=0.0970 and 0.6470 respectively) while manganese and selenium showed significant changes (p=0.0110 and <0.0001 respectively). Though correlations between malaria density and the levels of these antioxidants were relative and non-significant, copper, selenium and zinc showed positive relation while manganese showed negative relation. We are of the opinion that symptomatic malaria parasitemia induces extra oxidative stress on pregnant women. This calls for simultaneous determination of relevant antioxidants in suspected malaria parasitemia to help in better treatment and management of the disease, especially during pregnancy." @default.
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• W2116747718 date "2014-01-01" @default.
• W2116747718 modified "2023-09-26" @default.
• W2116747718 title "Oxidative Stress in Symptomatic Malaria Parasitemic Pregnant Women from Malaria Endemic Area of Nigeria" @default.
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